Synthesis, Characterization and HPLC Analysis of the (1S,2S,5R)-Diastereomer and the Enantiomer of the Clinical Candidate AR-15512

AR-15512 (formerly known as AVX-012 and WS-12) is a TRPM8 receptor agonist currently in phase 2b clinical trials for the treatment of dry eye. This bioactive compound with menthol-like cooling activity has three stereogenic centers, and its final structure and absolute configuration, (1R,2S,5R), hav...

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Detalles Bibliográficos
Autores principales: Rodríguez-Arévalo, Sergio, Pujol, Eugènia, Abás, Sònia, Galdeano, Carles, Escolano, Carmen, Vázquez, Santiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914790/
https://www.ncbi.nlm.nih.gov/pubmed/33572112
http://dx.doi.org/10.3390/molecules26040906

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914790/
https://www.ncbi.nlm.nih.gov/pubmed/33572112
http://dx.doi.org/10.3390/molecules26040906

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