The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target

Thioredoxin interacting protein (TXNIP) is a metabolism- oxidative- and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but...

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Detalles Bibliográficos
Autores principales: Domingues, Alison, Jolibois, Julia, Marquet de Rougé, Perrine, Nivet-Antoine, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914816/
https://www.ncbi.nlm.nih.gov/pubmed/33567593
http://dx.doi.org/10.3390/ijms22041693
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author Domingues, Alison
Jolibois, Julia
Marquet de Rougé, Perrine
Nivet-Antoine, Valérie
author_facet Domingues, Alison
Jolibois, Julia
Marquet de Rougé, Perrine
Nivet-Antoine, Valérie
author_sort Domingues, Alison
collection PubMed
description Thioredoxin interacting protein (TXNIP) is a metabolism- oxidative- and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases.
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spelling pubmed-79148162021-03-01 The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target Domingues, Alison Jolibois, Julia Marquet de Rougé, Perrine Nivet-Antoine, Valérie Int J Mol Sci Review Thioredoxin interacting protein (TXNIP) is a metabolism- oxidative- and inflammation-related marker induced in cardiovascular diseases and is believed to represent a possible link between metabolism and cellular redox status. TXNIP is a potential biomarker in cardiovascular and ischemic diseases but also a novel identified target for preventive and curative medicine. The goal of this review is to focus on the novelties concerning TXNIP. After an overview in TXNIP involvement in oxidative stress, inflammation and metabolism, the remainder of this review presents the clues used to define TXNIP as a new marker at the genetic, blood, or ischemic site level in the context of cardiovascular and ischemic diseases. MDPI 2021-02-08 /pmc/articles/PMC7914816/ /pubmed/33567593 http://dx.doi.org/10.3390/ijms22041693 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Domingues, Alison
Jolibois, Julia
Marquet de Rougé, Perrine
Nivet-Antoine, Valérie
The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title_full The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title_fullStr The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title_full_unstemmed The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title_short The Emerging Role of TXNIP in Ischemic and Cardiovascular Diseases; A Novel Marker and Therapeutic Target
title_sort emerging role of txnip in ischemic and cardiovascular diseases; a novel marker and therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914816/
https://www.ncbi.nlm.nih.gov/pubmed/33567593
http://dx.doi.org/10.3390/ijms22041693
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