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Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates

An efficient synthetic route to highly substituted dihydroquinolines and dihydronaphthyridines has been developed using a domino reaction of Morita-Baylis-Hillman (MBH) acetates with primary aliphatic and aromatic amines in DMF at 50–90 °C. The MBH substrates incorporate a side chain acetate positio...

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Autores principales: Annor-Gyamfi, Joel K., Ametsetor, Ebenezer, Meraz, Kevin, Bunce, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914960/
https://www.ncbi.nlm.nih.gov/pubmed/33567678
http://dx.doi.org/10.3390/molecules26040890
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author Annor-Gyamfi, Joel K.
Ametsetor, Ebenezer
Meraz, Kevin
Bunce, Richard A.
author_facet Annor-Gyamfi, Joel K.
Ametsetor, Ebenezer
Meraz, Kevin
Bunce, Richard A.
author_sort Annor-Gyamfi, Joel K.
collection PubMed
description An efficient synthetic route to highly substituted dihydroquinolines and dihydronaphthyridines has been developed using a domino reaction of Morita-Baylis-Hillman (MBH) acetates with primary aliphatic and aromatic amines in DMF at 50–90 °C. The MBH substrates incorporate a side chain acetate positioned adjacent to an acrylate or acrylonitrile aza-Michael acceptor as well as an aromatic ring activated toward S(N)Ar ring closure. A control experiment established that the initial reaction was an S(N)2′-type displacement of the side chain acetate by the amine to generate the alkene product with the added nitrogen nucleophile positioned trans to the S(N)Ar aromatic ring acceptor. Thus, equilibration of the initial alkene geometry is required prior to cyclization. A further double bond migration was observed for several reactions targeting dihydronaphthyridines from substrates with a side chain acrylonitrile moiety. MBH acetates incorporating a 2,5-difluorophenyl moiety were found to have dual reactivity in these annulations. In the absence of O(2), the expected dihydroquinolines were formed, while in the presence of O(2), quinolones were produced. All of the products were isolated in good to excellent yields (72–93%). Numerous cases (42) are reported, and mechanisms are discussed.
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spelling pubmed-79149602021-03-01 Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates Annor-Gyamfi, Joel K. Ametsetor, Ebenezer Meraz, Kevin Bunce, Richard A. Molecules Article An efficient synthetic route to highly substituted dihydroquinolines and dihydronaphthyridines has been developed using a domino reaction of Morita-Baylis-Hillman (MBH) acetates with primary aliphatic and aromatic amines in DMF at 50–90 °C. The MBH substrates incorporate a side chain acetate positioned adjacent to an acrylate or acrylonitrile aza-Michael acceptor as well as an aromatic ring activated toward S(N)Ar ring closure. A control experiment established that the initial reaction was an S(N)2′-type displacement of the side chain acetate by the amine to generate the alkene product with the added nitrogen nucleophile positioned trans to the S(N)Ar aromatic ring acceptor. Thus, equilibration of the initial alkene geometry is required prior to cyclization. A further double bond migration was observed for several reactions targeting dihydronaphthyridines from substrates with a side chain acrylonitrile moiety. MBH acetates incorporating a 2,5-difluorophenyl moiety were found to have dual reactivity in these annulations. In the absence of O(2), the expected dihydroquinolines were formed, while in the presence of O(2), quinolones were produced. All of the products were isolated in good to excellent yields (72–93%). Numerous cases (42) are reported, and mechanisms are discussed. MDPI 2021-02-08 /pmc/articles/PMC7914960/ /pubmed/33567678 http://dx.doi.org/10.3390/molecules26040890 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Annor-Gyamfi, Joel K.
Ametsetor, Ebenezer
Meraz, Kevin
Bunce, Richard A.
Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title_full Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title_fullStr Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title_full_unstemmed Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title_short Dihydroquinolines, Dihydronaphthyridines and Quinolones by Domino Reactions of Morita-Baylis-Hillman Acetates
title_sort dihydroquinolines, dihydronaphthyridines and quinolones by domino reactions of morita-baylis-hillman acetates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914960/
https://www.ncbi.nlm.nih.gov/pubmed/33567678
http://dx.doi.org/10.3390/molecules26040890
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