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Paroxetine—Overview of the Molecular Mechanisms of Action

In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and a...

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Autores principales: Kowalska, Magdalena, Nowaczyk, Jacek, Fijałkowski, Łukasz, Nowaczyk, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914979/
https://www.ncbi.nlm.nih.gov/pubmed/33562229
http://dx.doi.org/10.3390/ijms22041662
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author Kowalska, Magdalena
Nowaczyk, Jacek
Fijałkowski, Łukasz
Nowaczyk, Alicja
author_facet Kowalska, Magdalena
Nowaczyk, Jacek
Fijałkowski, Łukasz
Nowaczyk, Alicja
author_sort Kowalska, Magdalena
collection PubMed
description In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets.
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spelling pubmed-79149792021-03-01 Paroxetine—Overview of the Molecular Mechanisms of Action Kowalska, Magdalena Nowaczyk, Jacek Fijałkowski, Łukasz Nowaczyk, Alicja Int J Mol Sci Review In the 21st century and especially during a pandemic, the diagnosis and treatment of depression is an essential part of the daily practice of many family doctors. It mainly affects patients in the age category 15–44 years, regardless of gender. Anxiety disorders are often diagnosed in children and adolescents. Social phobias can account for up to 13% of these diagnoses. Social anxiety manifests itself in fear of negative social assessment and humiliation, which disrupts the quality of social functioning. Treatment of the above-mentioned disorders is based on psychotherapy and pharmacotherapy. Serious side effects or mortality from antidepressant drug overdose are currently rare. Recent studies indicate that paroxetine (ATC code: N06AB), belonging to the selective serotonin reuptake inhibitors, has promising therapeutic effects and is used off-label in children and adolescents. The purpose of this review is to describe the interaction of paroxetine with several molecular targets in various points of view including the basic chemical and pharmaceutical properties. The central point of the review is focused on the pharmacodynamic analysis based on the molecular mechanism of binding paroxetine to various therapeutic targets. MDPI 2021-02-07 /pmc/articles/PMC7914979/ /pubmed/33562229 http://dx.doi.org/10.3390/ijms22041662 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kowalska, Magdalena
Nowaczyk, Jacek
Fijałkowski, Łukasz
Nowaczyk, Alicja
Paroxetine—Overview of the Molecular Mechanisms of Action
title Paroxetine—Overview of the Molecular Mechanisms of Action
title_full Paroxetine—Overview of the Molecular Mechanisms of Action
title_fullStr Paroxetine—Overview of the Molecular Mechanisms of Action
title_full_unstemmed Paroxetine—Overview of the Molecular Mechanisms of Action
title_short Paroxetine—Overview of the Molecular Mechanisms of Action
title_sort paroxetine—overview of the molecular mechanisms of action
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914979/
https://www.ncbi.nlm.nih.gov/pubmed/33562229
http://dx.doi.org/10.3390/ijms22041662
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