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Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and...

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Autores principales: Lu, Chia-Wen, Lee, Yi-Chen, Kuo, Chia-Sheng, Chiang, Chien-Hsieh, Chang, Hao-Hsiang, Huang, Kuo-Chin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914992/
https://www.ncbi.nlm.nih.gov/pubmed/33562398
http://dx.doi.org/10.3390/nu13020548
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author Lu, Chia-Wen
Lee, Yi-Chen
Kuo, Chia-Sheng
Chiang, Chien-Hsieh
Chang, Hao-Hsiang
Huang, Kuo-Chin
author_facet Lu, Chia-Wen
Lee, Yi-Chen
Kuo, Chia-Sheng
Chiang, Chien-Hsieh
Chang, Hao-Hsiang
Huang, Kuo-Chin
author_sort Lu, Chia-Wen
collection PubMed
description The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.
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spelling pubmed-79149922021-03-01 Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome Lu, Chia-Wen Lee, Yi-Chen Kuo, Chia-Sheng Chiang, Chien-Hsieh Chang, Hao-Hsiang Huang, Kuo-Chin Nutrients Article The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance. MDPI 2021-02-07 /pmc/articles/PMC7914992/ /pubmed/33562398 http://dx.doi.org/10.3390/nu13020548 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Chia-Wen
Lee, Yi-Chen
Kuo, Chia-Sheng
Chiang, Chien-Hsieh
Chang, Hao-Hsiang
Huang, Kuo-Chin
Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title_full Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title_fullStr Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title_full_unstemmed Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title_short Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome
title_sort association of serum levels of zinc, copper, and iron with risk of metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7914992/
https://www.ncbi.nlm.nih.gov/pubmed/33562398
http://dx.doi.org/10.3390/nu13020548
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