Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors

Herein, a series of novel hybrid sulfaguanidine moieties, bearing 2-cyanoacrylamide 2a–d, pyridine-2-one 3–10, and 2-imino-2H-chromene-3-carboxamide 11, 12 derivatives, were synthesized, and their structure confirmed by spectral data and elemental analysis. All the synthesized compounds showed moder...

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Detalles Bibliográficos
Autores principales: Ragab, Ahmed, Fouad, Sawsan A., Ali, Ola A. Abu, Ahmed, Entsar M., Ali, Abeer M., Askar, Ahmed A., Ammar, Yousry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915026/
https://www.ncbi.nlm.nih.gov/pubmed/33562582
http://dx.doi.org/10.3390/antibiotics10020162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915026/
https://www.ncbi.nlm.nih.gov/pubmed/33562582
http://dx.doi.org/10.3390/antibiotics10020162

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