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The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for...

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Detalles Bibliográficos
Autores principales: Mencke, Pauline, Boussaad, Ibrahim, Romano, Chiara D., Kitami, Toshimori, Linster, Carole L., Krüger, Rejko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915027/
https://www.ncbi.nlm.nih.gov/pubmed/33562311
http://dx.doi.org/10.3390/cells10020347
Descripción
Sumario:DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.