The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for...

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Autores principales: Mencke, Pauline, Boussaad, Ibrahim, Romano, Chiara D., Kitami, Toshimori, Linster, Carole L., Krüger, Rejko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915027/
https://www.ncbi.nlm.nih.gov/pubmed/33562311
http://dx.doi.org/10.3390/cells10020347
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author Mencke, Pauline
Boussaad, Ibrahim
Romano, Chiara D.
Kitami, Toshimori
Linster, Carole L.
Krüger, Rejko
author_facet Mencke, Pauline
Boussaad, Ibrahim
Romano, Chiara D.
Kitami, Toshimori
Linster, Carole L.
Krüger, Rejko
author_sort Mencke, Pauline
collection PubMed
description DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.
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spelling pubmed-79150272021-03-01 The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease Mencke, Pauline Boussaad, Ibrahim Romano, Chiara D. Kitami, Toshimori Linster, Carole L. Krüger, Rejko Cells Review DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease. MDPI 2021-02-07 /pmc/articles/PMC7915027/ /pubmed/33562311 http://dx.doi.org/10.3390/cells10020347 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mencke, Pauline
Boussaad, Ibrahim
Romano, Chiara D.
Kitami, Toshimori
Linster, Carole L.
Krüger, Rejko
The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title_full The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title_fullStr The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title_full_unstemmed The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title_short The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease
title_sort role of dj-1 in cellular metabolism and pathophysiological implications for parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915027/
https://www.ncbi.nlm.nih.gov/pubmed/33562311
http://dx.doi.org/10.3390/cells10020347
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