Cargando…
The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction
The presence of a well-developed collateral circulation in the area of the artery responsible for the infarction improves the prognosis of patients and leads to a smaller area of infarction. One of the factors influencing the formation of collateral circulation is hypoxia, which induces angiogenesis...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915043/ https://www.ncbi.nlm.nih.gov/pubmed/33572082 http://dx.doi.org/10.3390/ijerph18041633 |
_version_ | 1783657145425723392 |
---|---|
author | Nowak-Lis, Agata Gabryś, Tomasz Nowak, Zbigniew Jastrzębski, Paweł Szmatlan-Gabryś, Urszula Konarska, Anna Grzybowska-Ganszczyk, Dominika Pilis, Anna |
author_facet | Nowak-Lis, Agata Gabryś, Tomasz Nowak, Zbigniew Jastrzębski, Paweł Szmatlan-Gabryś, Urszula Konarska, Anna Grzybowska-Ganszczyk, Dominika Pilis, Anna |
author_sort | Nowak-Lis, Agata |
collection | PubMed |
description | The presence of a well-developed collateral circulation in the area of the artery responsible for the infarction improves the prognosis of patients and leads to a smaller area of infarction. One of the factors influencing the formation of collateral circulation is hypoxia, which induces angiogenesis and arteriogenesis, which in turn cause the formation of new vessels. The aim of this study was to assess the effect of endurance training conducted under normobaric hypoxia in patients after myocardial infarction at the level of exercise tolerance and hemodynamic parameters of the left ventricle. Thirty-five patients aged 43–74 (60.48 ± 4.36) years who underwent angioplasty with stent implantation were examined. The program included 21 training units lasting about 90 min. A statistically significant improvement in exercise tolerance assessed with the cardiopulmonary exercise test (CPET) was observed: test duration (p < 0.001), distance covered (p < 0.001), HRmax (p = 0.039), maximal systolic blood pressure (SBPmax) (p = 0.044), peak minute ventilation (VE) (p = 0.004) and breathing frequency (BF) (p = 0.044). Favorable changes in left ventricular hemodynamic parameters were found for left ventricular end-diastolic dimension LVEDD (p = 0.002), left ventricular end-systolic dimension LVESD (p = 0.015), left ventricular ejection fraction (LVEF) (p = 0.021), lateral e’ (p < 0.001), septal e’ (p = 0.001), and E/A (p = 0.047). Endurance training conducted in hypoxic conditions has a positive effect on exercise tolerance and the hemodynamic indicators of the left ventricle. |
format | Online Article Text |
id | pubmed-7915043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79150432021-03-01 The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction Nowak-Lis, Agata Gabryś, Tomasz Nowak, Zbigniew Jastrzębski, Paweł Szmatlan-Gabryś, Urszula Konarska, Anna Grzybowska-Ganszczyk, Dominika Pilis, Anna Int J Environ Res Public Health Article The presence of a well-developed collateral circulation in the area of the artery responsible for the infarction improves the prognosis of patients and leads to a smaller area of infarction. One of the factors influencing the formation of collateral circulation is hypoxia, which induces angiogenesis and arteriogenesis, which in turn cause the formation of new vessels. The aim of this study was to assess the effect of endurance training conducted under normobaric hypoxia in patients after myocardial infarction at the level of exercise tolerance and hemodynamic parameters of the left ventricle. Thirty-five patients aged 43–74 (60.48 ± 4.36) years who underwent angioplasty with stent implantation were examined. The program included 21 training units lasting about 90 min. A statistically significant improvement in exercise tolerance assessed with the cardiopulmonary exercise test (CPET) was observed: test duration (p < 0.001), distance covered (p < 0.001), HRmax (p = 0.039), maximal systolic blood pressure (SBPmax) (p = 0.044), peak minute ventilation (VE) (p = 0.004) and breathing frequency (BF) (p = 0.044). Favorable changes in left ventricular hemodynamic parameters were found for left ventricular end-diastolic dimension LVEDD (p = 0.002), left ventricular end-systolic dimension LVESD (p = 0.015), left ventricular ejection fraction (LVEF) (p = 0.021), lateral e’ (p < 0.001), septal e’ (p = 0.001), and E/A (p = 0.047). Endurance training conducted in hypoxic conditions has a positive effect on exercise tolerance and the hemodynamic indicators of the left ventricle. MDPI 2021-02-09 2021-02 /pmc/articles/PMC7915043/ /pubmed/33572082 http://dx.doi.org/10.3390/ijerph18041633 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nowak-Lis, Agata Gabryś, Tomasz Nowak, Zbigniew Jastrzębski, Paweł Szmatlan-Gabryś, Urszula Konarska, Anna Grzybowska-Ganszczyk, Dominika Pilis, Anna The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title | The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title_full | The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title_fullStr | The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title_full_unstemmed | The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title_short | The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction |
title_sort | use of artificial hypoxia in endurance training in patients after myocardial infarction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915043/ https://www.ncbi.nlm.nih.gov/pubmed/33572082 http://dx.doi.org/10.3390/ijerph18041633 |
work_keys_str_mv | AT nowaklisagata theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT gabrystomasz theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT nowakzbigniew theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT jastrzebskipaweł theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT szmatlangabrysurszula theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT konarskaanna theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT grzybowskaganszczykdominika theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT pilisanna theuseofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT nowaklisagata useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT gabrystomasz useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT nowakzbigniew useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT jastrzebskipaweł useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT szmatlangabrysurszula useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT konarskaanna useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT grzybowskaganszczykdominika useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction AT pilisanna useofartificialhypoxiainendurancetraininginpatientsaftermyocardialinfarction |