Cargando…

Repurposing of Omarigliptin as a Neuroprotective Agent Based on Docking with A(2A) Adenosine and AChE Receptors, Brain GLP-1 Response and Its Brain/Plasma Concentration Ratio after 28 Days Multiple Doses in Rats Using LC-MS/MS

The authors in the current work suggested the potential repurposing of omarigliptin (OMR) for neurodegenerative diseases based on three new findings that support the preliminary finding of crossing BBB after a single dose study in the literature. The first finding is the positive results of the dock...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ayoub, Bassam M., Michel, Haidy E., Mowaka, Shereen, Hendy, Moataz S., Tadros, Mariam M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915074/ https://www.ncbi.nlm.nih.gov/pubmed/33567615 http://dx.doi.org/10.3390/molecules26040889

Ejemplares similares

Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population
por: Mowaka, Shereen, et al.
Publicado: (2021)

Enhanced Extraction Technique of Omarigliptin from Human Plasma—Applied to Biological Samples from Healthy Human Volunteers
por: Mowaka, Shereen, et al.
Publicado: (2020)

Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent
por: Ayoub, Bassam M., et al.
Publicado: (2018)

Pharmacokinetic Evaluation of Empagliflozin in Healthy Egyptian Volunteers Using LC-MS/MS and Comparison with Other Ethnic Populations
por: Ayoub, Bassam M., et al.
Publicado: (2017)

Comparative Liquid Chromatographic Study for Concurrent Determination of Canagliflozin and Metformin in Combined Tablets
por: Zaghary, Wafaa A., et al.
Publicado: (2017)

Plasmalogen Profiling in Porcine Brain Tissues by LC-MS/MS
por: Wu, Yue, et al.
Publicado: (2023)

Determination of Scopolamine Distribution in Plasma and Brain by LC-MS/MS in Rats
por: Chen, Juan, et al.
Publicado: (2022)

LC-MS/MS for Ultra-Sensitive Quantification of Multiple Estrogens in the Blood and Brain
por: Jalabert, Cecilia, et al.
Publicado: (2021)

Simultaneous Quantification of Pioglitazone and Omarigliptin in Rat Plasma by UHPLC-MS/MS and Its Application to Pharmacokinetic Study after Coadministration of the Two Drugs
por: Wang, Lin, et al.
Publicado: (2021)

Ultrasensitive Quantification of Multiple Estrogens in Songbird Blood and Microdissected Brain by LC-MS/MS
por: Jalabert, Cecilia, et al.
Publicado: (2022)

LC–MS/MS and GC–MS profiling as well as the antimicrobial effect of leaves of selected Yucca species introduced to Egypt
por: El Sayed, Abeer M., et al.
Publicado: (2020)

LC, MS(n) and LC–MS/MS studies for the characterization of degradation products of amlodipine
por: Tiwari, Ravi N., et al.
Publicado: (2015)

Tissue pretreatment for LC–MS/MS analysis of PUFA and eicosanoid distribution in mouse brain and liver
por: Reinicke, Madlen, et al.
Publicado: (2019)

Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage
por: Zhang, Yan, et al.
Publicado: (2023)

Economic Spectrofluorometric Bioanalysis of Empagliflozin in Rats' Plasma
por: Ayoub, Bassam, et al.
Publicado: (2021)

Fecal metabolite analysis of Japanese macaques in Yakushima by LC-MS/MS and LC-QTOF-MS
por: TSUCHIDA, Sayaka, et al.
Publicado: (2021)

Largazole Pharmacokinetics in Rats by LC-MS/MS
por: Yu, Mingming, et al.
Publicado: (2014)

Application of LC–MS/MS in the Mycotoxins Studies
por: Gámiz-Gracia, Laura, et al.
Publicado: (2020)

Comparison of Flow Injection-MS/MS and LC-MS/MS for the Determination of Ochratoxin A
por: Zhang, Kai
Publicado: (2021)

LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
por: Rakibe, Uday, et al.
Publicado: (2018)

Sterol Characteristics in Silkworm Brain and Various Tissues Characterized by Precise Sterol Profiling Using LC-MS/MS
por: Takeshima, Mika, et al.
Publicado: (2019)

Development and Validation of an LC-MS/MS Method and Comparison with a GC-MS Method to Measure Phenytoin in Human Brain Dialysate, Blood, and Saliva
por: Hösli, Raphael, et al.
Publicado: (2018)

Evaluation of LC-MS and LC×LC-MS in analysis of zebrafish embryo samples for comprehensive lipid profiling
por: Xu, Mengmeng, et al.
Publicado: (2020)

Integrated LC-MS/MS system for plant metabolomics
por: Sawada, Yuji, et al.
Publicado: (2013)

Determination of Nine Fentanyl Drugs in Hair Samples by GC-MS/MS and LC-MS/MS
por: Wei, Qi, et al.
Publicado: (2022)

Determination of 355 Pesticides in Lemon and Lemon Juice by LC-MS/MS and GC-MS/MS
por: Aslantas, Sule, et al.
Publicado: (2023)

The Quality Assessment of Commercial Lycium Berries Using LC-ESI-MS/MS and Chemometrics
por: Jarouche, Mariam, et al.
Publicado: (2019)

Simultaneous Quantification of Brigatinib and Brigatinib-Analog in Rat Plasma and Brain Homogenate by LC-MS/MS: Application to Comparative Pharmacokinetic and Brain Distribution Studies
por: Li, Bo, et al.
Publicado: (2019)

Comparative study on brain pharmacokinetics of Buyang Huanwu Decoction in normal and cerebral ischemia rats using brain microdialysis combined with LC-MS/MS
por: Liu, Wanyi, et al.
Publicado: (2022)

Development of dried blood spot quality control materials for adenosine deaminase severe combined immunodeficiency and an LC-MS/MS method for their characterization
por: Young, Brian, et al.
Publicado: (2020)

Pigments’ analysis of Citrus juicing making by‐products by LC‐MS/MS and LC‐DAD
por: Myrtsi, Eleni D., et al.
Publicado: (2022)

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS
por: Lam, Anh K., et al.
Publicado: (2022)

Omarigliptin Protects the Integrity of the Blood–Brain Barrier After Intracerebral Hemorrhage in Mice
por: Zhang, Yan, et al.
Publicado: (2023)

Identification of brain-enriched proteins in the cerebrospinal fluid proteome by LC-MS/MS profiling and mining of the Human Protein Atlas
por: Begcevic, Ilijana, et al.
Publicado: (2016)

LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose
por: Noorani, Behnam, et al.
Publicado: (2020)

Stoichiometric Quantification of Akt Phosphorylation Using LC-MS/MS
por: Atrih, Abdelmadjid, et al.
Publicado: (2009)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

Optimal precursor ion selection for LC-MALDI MS/MS
por: Zerck, Alexandra, et al.
Publicado: (2013)

Characterization of the Oxidative Degradation Product of Darunavir by LC-MS/MS
por: Yamjala, Karthik, et al.
Publicado: (2015)

Visualization of LC‐MS/MS proteomics data in MaxQuant
por: Tyanova, Stefka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_6n54h20fa2eam2b26q6v8rl6eq