Cargando…

Amino Acid Transporter LAT1 (SLC7A5) Mediates MeHg-Induced Oxidative Stress Defense in the Human Placental Cell Line HTR-8/SVneo

The placental barrier can protect the fetus from contact with harmful substances. The potent neurotoxin methylmercury (MeHg), however, is very efficiently transported across the placenta. Our previous data suggested that L-type amino acid transporter (LAT)1 is involved in placental MeHg uptake, acce...

Descripción completa

Detalles Bibliográficos
Autores principales:	Granitzer, Sebastian, Widhalm, Raimund, Forsthuber, Martin, Ellinger, Isabella, Desoye, Gernot, Hengstschläger, Markus, Zeisler, Harald, Salzer, Hans, Gundacker, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915079/ https://www.ncbi.nlm.nih.gov/pubmed/33567754 http://dx.doi.org/10.3390/ijms22041707

Ejemplares similares

In vitro function and in situ localization of Multidrug Resistance-associated Protein (MRP)1 (ABCC1) suggest a protective role against methyl mercury-induced oxidative stress in the human placenta
por: Granitzer, Sebastian, et al.
Publicado: (2020)

Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter
por: Balthasar, Christina, et al.
Publicado: (2017)

BDNF and KISS-1 Levels in Maternal Serum, Umbilical Cord, and Placenta: The Potential Role of Maternal Levels as Effect Biomarker
por: Granitzer, Sebastian, et al.
Publicado: (2023)

Diverse Methylmercury (MeHg) Producers and Degraders Inhabit Acid Mine Drainage Sediments, but Few Taxa Correlate with MeHg Accumulation
por: Zheng, Jin, et al.
Publicado: (2022)

Role of Calcium and Mitochondria in MeHg-Mediated Cytotoxicity
por: Roos, Daniel, et al.
Publicado: (2012)

Valproate, thalidomide and ethyl alcohol alter the migration of HTR-8/SVneo cells
por: Rout, Ujjwal K
Publicado: (2006)

Developmental Exposure to PCBs, MeHg, or Both: Long-Term Effects on Auditory Function
por: Powers, Brian E., et al.
Publicado: (2009)

Catch of the Decade: Changes in U.S. Seafood Consumption and MeHg Intake over Time
por: Potera, Carol
Publicado: (2018)

Exposure to environmental bisphenol A inhibits HTR-8/SVneo cell migration and invasion
por: Wei, Pu, et al.
Publicado: (2020)

Metabolic disparities of different oxidative stress-inducing conditions in HTR8/SVneo cells
por: Chen, Jingdong, et al.
Publicado: (2020)

Chemical speciation of MeHg(+) and Hg(2+) in aqueous solution and HEK cells nuclei by means of DNA interacting fluorogenic probes
por: Díaz de Greñu, Borja, et al.
Publicado: (2015)

Identification of sources and bioaccumulation pathways of MeHg in subantarctic penguins: a stable isotopic investigation
por: Renedo, Marina, et al.
Publicado: (2018)

MeHg Causes Ultrastructural Changes in Mitochondria and Autophagy in the Spinal Cord Cells of Chicken Embryo
por: Ferreira, Fabiana F., et al.
Publicado: (2018)

Autophagy in the HTR-8/SVneo Cell Oxidative Stress Model Is Associated with the NLRP1 Inflammasome
por: Li, Meihe, et al.
Publicado: (2021)

N-Acetylcysteine Displaces Glutathionyl-Moieties from Hg(2+) and MeHg(+) to Form More Hydrophobic Complexes at Near-Physiological Conditions
por: Doroudian, Maryam, et al.
Publicado: (2023)

Exposure to Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells
por: Elkin, Elana R., et al.
Publicado: (2020)

Mechanistic understanding of MeHg-Se antagonism in soil-rice systems: the key role of antagonism in soil
por: Wang, Yongjie, et al.
Publicado: (2016)

Gestational Age and Sex Influence the Susceptibility of Human Neural Progenitor Cells to Low Levels of MeHg
por: Edoff, Karin, et al.
Publicado: (2017)

Projected amplification of food web bioaccumulation of MeHg and PCBs under climate change in the Northeastern Pacific
por: Alava, Juan José, et al.
Publicado: (2018)

Extractable Organofluorine Analysis in Pooled Human Serum and Placental Tissue Samples from an Austrian Subpopulation—A Mass Balance Analysis Approach
por: Kaiser, Andreas-Marius, et al.
Publicado: (2021)

Effects of transforming growth factor-β1 on the proliferation and invasion of the HTR-8/SVneo cell line
por: ZUO, YANZHEN, et al.
Publicado: (2014)

Serum depletion induces changes in protein expression in the trophoblast-derived cell line HTR-8/SVneo
por: Novoa-Herran, Susana, et al.
Publicado: (2016)

Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells
por: Wang, Xianli, et al.
Publicado: (2022)

Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity
por: Zafaranieh, Saghi, et al.
Publicado: (2022)

Associations of maternal immune response with MeHg exposure at 28 weeks’ gestation in the Seychelles Child Development Study
por: McSorley, Emeir M., et al.
Publicado: (2018)

DHA ameliorates MeHg-induced PC12 cell apoptosis by inhibiting the ROS/JNK signaling pathway
por: Zhang, Hong, et al.
Publicado: (2021)

Total mercury and methylmercury (MeHg) in braised and crude Boletus edulis carpophores during various developmental stages
por: Falandysz, Jerzy, et al.
Publicado: (2021)

Hepatocyte growth factor regulates HLX1 gene expression to modulate HTR-8/SVneo trophoblast cells
por: Liu, Hai-Ying, et al.
Publicado: (2012)

IGFBP-4 and −5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells
por: Crosley, Erin J, et al.
Publicado: (2014)

GABA A receptor π subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia
por: LU, JUNJIE, et al.
Publicado: (2016)

Interdependence of JAK-STAT and MAPK signaling pathways during EGF-mediated HTR-8/SVneo cell invasion
por: Malik, Ankita, et al.
Publicado: (2017)

Effects of low doses of methylmercury (MeHg) exposure on definitive endoderm cell differentiation in human embryonic stem cells
por: Li, Bai, et al.
Publicado: (2023)

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder
por: Oguro, Ami, et al.
Publicado: (2023)

BMP9 maintains the phenotype of HTR-8/Svneo trophoblast cells by activating the SDF1/CXCR4 pathway
por: Yang, Xue, et al.
Publicado: (2023)

Reduced Birth Weight and Exposure to Per- and Polyfluoroalkyl Substances: A Review of Possible Underlying Mechanisms Using the AOP-HelpFinder
por: Gundacker, Claudia, et al.
Publicado: (2022)

Epigenetic adaptation of the placental serotonin transporter gene (SLC6A4) to gestational diabetes mellitus
por: Blazevic, Sofia, et al.
Publicado: (2017)

MeHg Developing Exposure Causes DNA Double-Strand Breaks and Elicits Cell Cycle Arrest in Spinal Cord Cells
por: Ferreira, Fabiana F., et al.
Publicado: (2015)

MeHg-induced autophagy via JNK/Vps34 complex pathway promotes autophagosome accumulation and neuronal cell death
por: Lin, Tianji, et al.
Publicado: (2019)

Isolation and Characterization of Human Trophoblast Side-Population (SP) Cells in Primary Villous Cytotrophoblasts and HTR-8/SVneo Cell Line
por: Takao, Tomoka, et al.
Publicado: (2011)

CTGF expression is up-regulated by PROK1 in early pregnancy and influences HTR-8/Svneo cell adhesion and network formation
por: Waddell, Jennifer M., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_pna56hbh9r9vqvlcbt5ned51f6