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Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study

(1) Background: Elizabethkingia spp. is an emerging nosocomial pathogen which causes mostly blood stream infection and nosocomial pneumonia. Among Elizabethkingia species, Elizabethkingia anophelis is the major pathogen, but misidentification as Elizabethkingia meningoseptica is a common problem. El...

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Autores principales: Teng, Ling-Chiao, Wang, Jiunn-Min, Lu, Hsueh-Yin, Mao, Yan-Chiao, Lai, Kuo-Lung, Tseng, Chien-Hao, Huang, Yao-Ting, Liu, Po-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915159/
https://www.ncbi.nlm.nih.gov/pubmed/33572268
http://dx.doi.org/10.3390/antibiotics10020173
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author Teng, Ling-Chiao
Wang, Jiunn-Min
Lu, Hsueh-Yin
Mao, Yan-Chiao
Lai, Kuo-Lung
Tseng, Chien-Hao
Huang, Yao-Ting
Liu, Po-Yu
author_facet Teng, Ling-Chiao
Wang, Jiunn-Min
Lu, Hsueh-Yin
Mao, Yan-Chiao
Lai, Kuo-Lung
Tseng, Chien-Hao
Huang, Yao-Ting
Liu, Po-Yu
author_sort Teng, Ling-Chiao
collection PubMed
description (1) Background: Elizabethkingia spp. is an emerging nosocomial pathogen which causes mostly blood stream infection and nosocomial pneumonia. Among Elizabethkingia species, Elizabethkingia anophelis is the major pathogen, but misidentification as Elizabethkingia meningoseptica is a common problem. Elizabethkingia also possesses broad antibiotic resistance, resulting in high morbidity and mortality of the infection. The aim of our study was to review Elizabethkingia intra-abdominal infections and investigate resistance mechanisms against TMP/SMX in Elizabethkingia anophelis by whole genome sequencing. (2) Methods: We retrospectively searched records of patients with Elizabethkingia intra-abdominal infection between 1990 and 2019. We also conducted whole genome sequencing for a TMP/SMX-resistant Elizabethkingia anophelis to identify possible mechanisms of resistance. (3) Results: We identified a total of nine cases of Elizabethkingia intra-abdominal infection in a review of the literature, including our own case. The cases included three biliary tract infections, three CAPD-related infection, two with infected ascites, and two postoperation infections. Host factor, indwelling-catheter, and previous invasive procedure, including surgery, play important roles in Elizabethkingia infection. Removal of the catheter is crucial for successful treatment. Genomic analysis revealed accumulated mutations leading to TMP/SMX-resistance in folP. (4) Conclusions: Patients with underlying disease and indwelling catheter are more susceptible to Elizabethkingia intra-abdominal infection, and successful treatment requires removal of the catheter. The emerging resistance to TMP/SMX may be related to accumulated mutations in folP.
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spelling pubmed-79151592021-03-01 Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study Teng, Ling-Chiao Wang, Jiunn-Min Lu, Hsueh-Yin Mao, Yan-Chiao Lai, Kuo-Lung Tseng, Chien-Hao Huang, Yao-Ting Liu, Po-Yu Antibiotics (Basel) Article (1) Background: Elizabethkingia spp. is an emerging nosocomial pathogen which causes mostly blood stream infection and nosocomial pneumonia. Among Elizabethkingia species, Elizabethkingia anophelis is the major pathogen, but misidentification as Elizabethkingia meningoseptica is a common problem. Elizabethkingia also possesses broad antibiotic resistance, resulting in high morbidity and mortality of the infection. The aim of our study was to review Elizabethkingia intra-abdominal infections and investigate resistance mechanisms against TMP/SMX in Elizabethkingia anophelis by whole genome sequencing. (2) Methods: We retrospectively searched records of patients with Elizabethkingia intra-abdominal infection between 1990 and 2019. We also conducted whole genome sequencing for a TMP/SMX-resistant Elizabethkingia anophelis to identify possible mechanisms of resistance. (3) Results: We identified a total of nine cases of Elizabethkingia intra-abdominal infection in a review of the literature, including our own case. The cases included three biliary tract infections, three CAPD-related infection, two with infected ascites, and two postoperation infections. Host factor, indwelling-catheter, and previous invasive procedure, including surgery, play important roles in Elizabethkingia infection. Removal of the catheter is crucial for successful treatment. Genomic analysis revealed accumulated mutations leading to TMP/SMX-resistance in folP. (4) Conclusions: Patients with underlying disease and indwelling catheter are more susceptible to Elizabethkingia intra-abdominal infection, and successful treatment requires removal of the catheter. The emerging resistance to TMP/SMX may be related to accumulated mutations in folP. MDPI 2021-02-09 /pmc/articles/PMC7915159/ /pubmed/33572268 http://dx.doi.org/10.3390/antibiotics10020173 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Teng, Ling-Chiao
Wang, Jiunn-Min
Lu, Hsueh-Yin
Mao, Yan-Chiao
Lai, Kuo-Lung
Tseng, Chien-Hao
Huang, Yao-Ting
Liu, Po-Yu
Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title_full Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title_fullStr Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title_full_unstemmed Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title_short Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study
title_sort elizabethkingia intra-abdominal infection and related trimethoprim-sulfamethoxazole resistance: a clinical-genomic study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915159/
https://www.ncbi.nlm.nih.gov/pubmed/33572268
http://dx.doi.org/10.3390/antibiotics10020173
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