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Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes

Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comp...

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Autores principales: Song, Nuri, Jeong, Da Yeon, Tu, Thai Hien, Park, Byong Seo, Yang, Hye Rim, Kim, Ye Jin, Kim, Jae Kwang, Park, Joon Tae, Yeh, Jung-Yong, Yang, Sunggu, Kim, Jae Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915184/
https://www.ncbi.nlm.nih.gov/pubmed/33557390
http://dx.doi.org/10.3390/ijms22041587
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author Song, Nuri
Jeong, Da Yeon
Tu, Thai Hien
Park, Byong Seo
Yang, Hye Rim
Kim, Ye Jin
Kim, Jae Kwang
Park, Joon Tae
Yeh, Jung-Yong
Yang, Sunggu
Kim, Jae Geun
author_facet Song, Nuri
Jeong, Da Yeon
Tu, Thai Hien
Park, Byong Seo
Yang, Hye Rim
Kim, Ye Jin
Kim, Jae Kwang
Park, Joon Tae
Yeh, Jung-Yong
Yang, Sunggu
Kim, Jae Geun
author_sort Song, Nuri
collection PubMed
description Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus.
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spelling pubmed-79151842021-03-01 Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes Song, Nuri Jeong, Da Yeon Tu, Thai Hien Park, Byong Seo Yang, Hye Rim Kim, Ye Jin Kim, Jae Kwang Park, Joon Tae Yeh, Jung-Yong Yang, Sunggu Kim, Jae Geun Int J Mol Sci Article Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus. MDPI 2021-02-04 /pmc/articles/PMC7915184/ /pubmed/33557390 http://dx.doi.org/10.3390/ijms22041587 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Song, Nuri
Jeong, Da Yeon
Tu, Thai Hien
Park, Byong Seo
Yang, Hye Rim
Kim, Ye Jin
Kim, Jae Kwang
Park, Joon Tae
Yeh, Jung-Yong
Yang, Sunggu
Kim, Jae Geun
Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title_full Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title_fullStr Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title_full_unstemmed Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title_short Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
title_sort adiponectin controls nutrient availability in hypothalamic astrocytes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915184/
https://www.ncbi.nlm.nih.gov/pubmed/33557390
http://dx.doi.org/10.3390/ijms22041587
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