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Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes
Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comp...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915184/ https://www.ncbi.nlm.nih.gov/pubmed/33557390 http://dx.doi.org/10.3390/ijms22041587 |
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author | Song, Nuri Jeong, Da Yeon Tu, Thai Hien Park, Byong Seo Yang, Hye Rim Kim, Ye Jin Kim, Jae Kwang Park, Joon Tae Yeh, Jung-Yong Yang, Sunggu Kim, Jae Geun |
author_facet | Song, Nuri Jeong, Da Yeon Tu, Thai Hien Park, Byong Seo Yang, Hye Rim Kim, Ye Jin Kim, Jae Kwang Park, Joon Tae Yeh, Jung-Yong Yang, Sunggu Kim, Jae Geun |
author_sort | Song, Nuri |
collection | PubMed |
description | Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus. |
format | Online Article Text |
id | pubmed-7915184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79151842021-03-01 Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes Song, Nuri Jeong, Da Yeon Tu, Thai Hien Park, Byong Seo Yang, Hye Rim Kim, Ye Jin Kim, Jae Kwang Park, Joon Tae Yeh, Jung-Yong Yang, Sunggu Kim, Jae Geun Int J Mol Sci Article Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus. MDPI 2021-02-04 /pmc/articles/PMC7915184/ /pubmed/33557390 http://dx.doi.org/10.3390/ijms22041587 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Song, Nuri Jeong, Da Yeon Tu, Thai Hien Park, Byong Seo Yang, Hye Rim Kim, Ye Jin Kim, Jae Kwang Park, Joon Tae Yeh, Jung-Yong Yang, Sunggu Kim, Jae Geun Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title | Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title_full | Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title_fullStr | Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title_full_unstemmed | Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title_short | Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes |
title_sort | adiponectin controls nutrient availability in hypothalamic astrocytes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915184/ https://www.ncbi.nlm.nih.gov/pubmed/33557390 http://dx.doi.org/10.3390/ijms22041587 |
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