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The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully u...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915290/ https://www.ncbi.nlm.nih.gov/pubmed/33562110 http://dx.doi.org/10.3390/ijms22041653 |
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author | Yun, Dahye Yoon, So Young Park, Soo Jung Park, Yoon Jung |
author_facet | Yun, Dahye Yoon, So Young Park, Soo Jung Park, Yoon Jung |
author_sort | Yun, Dahye |
collection | PubMed |
description | Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment. |
format | Online Article Text |
id | pubmed-7915290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79152902021-03-01 The Anticancer Effect of Natural Plant Alkaloid Isoquinolines Yun, Dahye Yoon, So Young Park, Soo Jung Park, Yoon Jung Int J Mol Sci Review Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment. MDPI 2021-02-06 /pmc/articles/PMC7915290/ /pubmed/33562110 http://dx.doi.org/10.3390/ijms22041653 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yun, Dahye Yoon, So Young Park, Soo Jung Park, Yoon Jung The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title | The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title_full | The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title_fullStr | The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title_full_unstemmed | The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title_short | The Anticancer Effect of Natural Plant Alkaloid Isoquinolines |
title_sort | anticancer effect of natural plant alkaloid isoquinolines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915290/ https://www.ncbi.nlm.nih.gov/pubmed/33562110 http://dx.doi.org/10.3390/ijms22041653 |
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