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The Anticancer Effect of Natural Plant Alkaloid Isoquinolines

Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully u...

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Detalles Bibliográficos
Autores principales: Yun, Dahye, Yoon, So Young, Park, Soo Jung, Park, Yoon Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915290/
https://www.ncbi.nlm.nih.gov/pubmed/33562110
http://dx.doi.org/10.3390/ijms22041653
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author Yun, Dahye
Yoon, So Young
Park, Soo Jung
Park, Yoon Jung
author_facet Yun, Dahye
Yoon, So Young
Park, Soo Jung
Park, Yoon Jung
author_sort Yun, Dahye
collection PubMed
description Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.
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spelling pubmed-79152902021-03-01 The Anticancer Effect of Natural Plant Alkaloid Isoquinolines Yun, Dahye Yoon, So Young Park, Soo Jung Park, Yoon Jung Int J Mol Sci Review Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment. MDPI 2021-02-06 /pmc/articles/PMC7915290/ /pubmed/33562110 http://dx.doi.org/10.3390/ijms22041653 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yun, Dahye
Yoon, So Young
Park, Soo Jung
Park, Yoon Jung
The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title_full The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title_fullStr The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title_full_unstemmed The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title_short The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
title_sort anticancer effect of natural plant alkaloid isoquinolines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915290/
https://www.ncbi.nlm.nih.gov/pubmed/33562110
http://dx.doi.org/10.3390/ijms22041653
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