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Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood

The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metaboli...

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Autores principales: Lehtovirta, Miia, Matthews, Laurie A., Laitinen, Tomi T., Nuotio, Joel, Niinikoski, Harri, Rovio, Suvi P., Lagström, Hanna, Viikari, Jorma S. A., Rönnemaa, Tapani, Jula, Antti, Ala-Korpela, Mika, Raitakari, Olli T., Pahkala, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915301/
https://www.ncbi.nlm.nih.gov/pubmed/33562015
http://dx.doi.org/10.3390/nu13020533
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author Lehtovirta, Miia
Matthews, Laurie A.
Laitinen, Tomi T.
Nuotio, Joel
Niinikoski, Harri
Rovio, Suvi P.
Lagström, Hanna
Viikari, Jorma S. A.
Rönnemaa, Tapani
Jula, Antti
Ala-Korpela, Mika
Raitakari, Olli T.
Pahkala, Katja
author_facet Lehtovirta, Miia
Matthews, Laurie A.
Laitinen, Tomi T.
Nuotio, Joel
Niinikoski, Harri
Rovio, Suvi P.
Lagström, Hanna
Viikari, Jorma S. A.
Rönnemaa, Tapani
Jula, Antti
Ala-Korpela, Mika
Raitakari, Olli T.
Pahkala, Katja
author_sort Lehtovirta, Miia
collection PubMed
description The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metabolites were studied at six time points between the ages of 9–19 years (n = 549–338). Dietary targets for this study were defined as (1) the ratio of saturated fat (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) < 1:2, (2) intake of SAFA < 10% of total energy intake, (3) fiber intake ≥ 80th age-specific percentile, and (4) sucrose intake ≤ 20th age-specific percentile. Metabolic biomarkers were quantified by high-throughput nuclear magnetic resonance metabolomics. Better adherence to the dietary targets, regardless of study group allocation, was assoiated with higher serum proportion of PUFAs, lower serum proportion of SAFAs, and a higher degree of unsaturation of fatty acids. Achieving ≥ 1 dietary target resulted in higher low-density lipoprotein (LDL) particle size, lower circulating LDL subclass lipid concentrations, and lower circulating lipid concentrations in medium and small high-density lipoprotein subclasses compared to meeting 0 targets. Attaining more dietary targets (≥2) was associated with a tendency to lower lipid concentrations of intermediate-density lipoprotein and very low-density lipoprotein subclasses. Thus, adherence to dietary targets is favorably associated with multiple circulating fatty acids and lipoprotein subclass lipid concentrations, indicative of better cardio-metabolic health.
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spelling pubmed-79153012021-03-01 Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood Lehtovirta, Miia Matthews, Laurie A. Laitinen, Tomi T. Nuotio, Joel Niinikoski, Harri Rovio, Suvi P. Lagström, Hanna Viikari, Jorma S. A. Rönnemaa, Tapani Jula, Antti Ala-Korpela, Mika Raitakari, Olli T. Pahkala, Katja Nutrients Article The Special Turku Coronary Risk Factor Intervention Project (STRIP) is a prospective infancy-onset randomized dietary intervention trial targeting dietary fat quality and cholesterol intake, and favoring consumption of vegetables, fruit, and whole-grains. Diet (food records) and circulating metabolites were studied at six time points between the ages of 9–19 years (n = 549–338). Dietary targets for this study were defined as (1) the ratio of saturated fat (SAFA) to monounsaturated and polyunsaturated fatty acids (MUFA + PUFA) < 1:2, (2) intake of SAFA < 10% of total energy intake, (3) fiber intake ≥ 80th age-specific percentile, and (4) sucrose intake ≤ 20th age-specific percentile. Metabolic biomarkers were quantified by high-throughput nuclear magnetic resonance metabolomics. Better adherence to the dietary targets, regardless of study group allocation, was assoiated with higher serum proportion of PUFAs, lower serum proportion of SAFAs, and a higher degree of unsaturation of fatty acids. Achieving ≥ 1 dietary target resulted in higher low-density lipoprotein (LDL) particle size, lower circulating LDL subclass lipid concentrations, and lower circulating lipid concentrations in medium and small high-density lipoprotein subclasses compared to meeting 0 targets. Attaining more dietary targets (≥2) was associated with a tendency to lower lipid concentrations of intermediate-density lipoprotein and very low-density lipoprotein subclasses. Thus, adherence to dietary targets is favorably associated with multiple circulating fatty acids and lipoprotein subclass lipid concentrations, indicative of better cardio-metabolic health. MDPI 2021-02-06 /pmc/articles/PMC7915301/ /pubmed/33562015 http://dx.doi.org/10.3390/nu13020533 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lehtovirta, Miia
Matthews, Laurie A.
Laitinen, Tomi T.
Nuotio, Joel
Niinikoski, Harri
Rovio, Suvi P.
Lagström, Hanna
Viikari, Jorma S. A.
Rönnemaa, Tapani
Jula, Antti
Ala-Korpela, Mika
Raitakari, Olli T.
Pahkala, Katja
Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title_full Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title_fullStr Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title_full_unstemmed Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title_short Achievement of the Targets of the 20-Year Infancy-Onset Dietary Intervention—Association with Metabolic Profile from Childhood to Adulthood
title_sort achievement of the targets of the 20-year infancy-onset dietary intervention—association with metabolic profile from childhood to adulthood
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915301/
https://www.ncbi.nlm.nih.gov/pubmed/33562015
http://dx.doi.org/10.3390/nu13020533
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