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Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis
There has been an increase in the prevalence of gram-positive bacteremia in neonates in the last two decades. However, as a consequence of better care, there has been an increase in the survival of premature neonates. Coagulase-negative staphylococci (CoNS) is the most prevalent bacteria, responsibl...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915314/ https://www.ncbi.nlm.nih.gov/pubmed/33562197 http://dx.doi.org/10.3390/antibiotics10020168 |
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author | Mohzari, Yahya Aljobair, Fahad Alrashed, Ahmed Asdaq, Syed Mohammed Basheeruddin Alshuraim, Renad Abdullah Asfour, Suzan Suhail Al-Mouqdad, Mountasser Mohammad Bamogaddam, Reem F. Al-Anazi, Deemah Zeilinger, Catherine E. Alamer, Ahmad Alhassan, Batool Mohammed Sreeharsha, Nagaraja |
author_facet | Mohzari, Yahya Aljobair, Fahad Alrashed, Ahmed Asdaq, Syed Mohammed Basheeruddin Alshuraim, Renad Abdullah Asfour, Suzan Suhail Al-Mouqdad, Mountasser Mohammad Bamogaddam, Reem F. Al-Anazi, Deemah Zeilinger, Catherine E. Alamer, Ahmad Alhassan, Batool Mohammed Sreeharsha, Nagaraja |
author_sort | Mohzari, Yahya |
collection | PubMed |
description | There has been an increase in the prevalence of gram-positive bacteremia in neonates in the last two decades. However, as a consequence of better care, there has been an increase in the survival of premature neonates. Coagulase-negative staphylococci (CoNS) is the most prevalent bacteria, responsible for up to 60% of late-onset sepsis (LOS). Daptomycin, a lipopeptide antimicrobial agent, is active against CoNS. This was an observational, retrospective case series study carried out in the Pediatric Hospital of King Saud Medical City, Riyadh, Saudi Arabia. The medical records of 21 neonates, aged 0–28 days, who were treated in Neonatal Intensive Care Unit (NICU) with intravenous daptomycin as monotherapy or combination therapy for at least 4 days for proven gram-positive infection between June 2019 to July 2020, were included. The median gestational and chronological age were 27 weeks and 5 days, respectively. The most frequent diagnosis in neonates was infective endocarditis (42.9%). Of the 21 patients who received daptomycin therapy, 13 (62%) recovered and 8 died. The clinical cure rate was higher in Staphylococcus hominis (100%) and in patients who received 6 mg/kg/dose twice daily (62.5%). The mean of aspartate aminotransferase significantly elevated after starting daptomycin (p = 0.048). However, no muscular or neurological toxicity of daptomycin was documented in any of the cases. Overall, daptomycin was well tolerated, even with long-term treatment. |
format | Online Article Text |
id | pubmed-7915314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79153142021-03-01 Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis Mohzari, Yahya Aljobair, Fahad Alrashed, Ahmed Asdaq, Syed Mohammed Basheeruddin Alshuraim, Renad Abdullah Asfour, Suzan Suhail Al-Mouqdad, Mountasser Mohammad Bamogaddam, Reem F. Al-Anazi, Deemah Zeilinger, Catherine E. Alamer, Ahmad Alhassan, Batool Mohammed Sreeharsha, Nagaraja Antibiotics (Basel) Article There has been an increase in the prevalence of gram-positive bacteremia in neonates in the last two decades. However, as a consequence of better care, there has been an increase in the survival of premature neonates. Coagulase-negative staphylococci (CoNS) is the most prevalent bacteria, responsible for up to 60% of late-onset sepsis (LOS). Daptomycin, a lipopeptide antimicrobial agent, is active against CoNS. This was an observational, retrospective case series study carried out in the Pediatric Hospital of King Saud Medical City, Riyadh, Saudi Arabia. The medical records of 21 neonates, aged 0–28 days, who were treated in Neonatal Intensive Care Unit (NICU) with intravenous daptomycin as monotherapy or combination therapy for at least 4 days for proven gram-positive infection between June 2019 to July 2020, were included. The median gestational and chronological age were 27 weeks and 5 days, respectively. The most frequent diagnosis in neonates was infective endocarditis (42.9%). Of the 21 patients who received daptomycin therapy, 13 (62%) recovered and 8 died. The clinical cure rate was higher in Staphylococcus hominis (100%) and in patients who received 6 mg/kg/dose twice daily (62.5%). The mean of aspartate aminotransferase significantly elevated after starting daptomycin (p = 0.048). However, no muscular or neurological toxicity of daptomycin was documented in any of the cases. Overall, daptomycin was well tolerated, even with long-term treatment. MDPI 2021-02-07 /pmc/articles/PMC7915314/ /pubmed/33562197 http://dx.doi.org/10.3390/antibiotics10020168 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mohzari, Yahya Aljobair, Fahad Alrashed, Ahmed Asdaq, Syed Mohammed Basheeruddin Alshuraim, Renad Abdullah Asfour, Suzan Suhail Al-Mouqdad, Mountasser Mohammad Bamogaddam, Reem F. Al-Anazi, Deemah Zeilinger, Catherine E. Alamer, Ahmad Alhassan, Batool Mohammed Sreeharsha, Nagaraja Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title | Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title_full | Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title_fullStr | Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title_full_unstemmed | Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title_short | Safety and Efficacy of Daptomycin in Neonates with Coagulase-Negative Staphylococci: Case Series Analysis |
title_sort | safety and efficacy of daptomycin in neonates with coagulase-negative staphylococci: case series analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915314/ https://www.ncbi.nlm.nih.gov/pubmed/33562197 http://dx.doi.org/10.3390/antibiotics10020168 |
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