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Phytochemical Investigation and Biological Activities of Lantana rhodesiensis

Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids...

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Autores principales: Nea, Fatimata, Bitchi, Michel Boni, Genva, Manon, Ledoux, Allison, Tchinda, Alembert Tiabou, Damblon, Christian, Frederich, Michel, Tonzibo, Zanahi Félix, Fauconnier, Marie-Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915326/
https://www.ncbi.nlm.nih.gov/pubmed/33562771
http://dx.doi.org/10.3390/molecules26040846
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author Nea, Fatimata
Bitchi, Michel Boni
Genva, Manon
Ledoux, Allison
Tchinda, Alembert Tiabou
Damblon, Christian
Frederich, Michel
Tonzibo, Zanahi Félix
Fauconnier, Marie-Laure
author_facet Nea, Fatimata
Bitchi, Michel Boni
Genva, Manon
Ledoux, Allison
Tchinda, Alembert Tiabou
Damblon, Christian
Frederich, Michel
Tonzibo, Zanahi Félix
Fauconnier, Marie-Laure
author_sort Nea, Fatimata
collection PubMed
description Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the β-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3′,5′-tetrahydroxy-7,4′-dimethoxyflavone) (1), 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (3), and 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (4). Their structures were elucidated by (1)H, (13)CNMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species.
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spelling pubmed-79153262021-03-01 Phytochemical Investigation and Biological Activities of Lantana rhodesiensis Nea, Fatimata Bitchi, Michel Boni Genva, Manon Ledoux, Allison Tchinda, Alembert Tiabou Damblon, Christian Frederich, Michel Tonzibo, Zanahi Félix Fauconnier, Marie-Laure Molecules Article Lantana rhodesiensis Moldenke is a plant widely used to treat diseases, such as rheumatism, diabetes, and malaria in traditional medicine. To better understand the traditional uses of this plant, a phytochemical study was undertaken, revealing a higher proportion of polyphenols, including flavonoids in L. rhodesiensis leaf extract and moderate proportion in stem and root extracts. The antioxidant activity of the extracts was also determined using three different assays: the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, the FRAP method (Ferric-reducing antioxidant power) and the β-carotene bleaching test. The anti-malarial activity of each extract was also evaluated using asexual erythrocyte stages of Plasmodium falciparum, chloroquine-sensitive strain 3D7. The results showed that the leaf extract exhibited higher antioxidant and anti-malarial activities in comparison with the stem and root extracts, probably due to the presence of higher quantities of polyphenols including flavonoids in the leaves. A positive linear correlation was established between the phenolic compound content (total polyphenols including flavonoids and tannins; and total flavonoids) and the antioxidant activity of all extracts. Furthermore, four flavones were isolated from leaf dichloromethane and ethyl acetate fractions: a new flavone named rhodescine (5,6,3′,5′-tetrahydroxy-7,4′-dimethoxyflavone) (1), 5-hydroxy-6,7,3′,4′,5′-pentamethoxyflavone (2), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (3), and 5,6,3′-trihydroxy-7,4′-dimethoxyflavone (4). Their structures were elucidated by (1)H, (13)CNMR, COSY, HSQC, HMBC, and MS-EI spectral methods. Aside from compound 2, all other molecules were described for the first time in this plant species. MDPI 2021-02-05 /pmc/articles/PMC7915326/ /pubmed/33562771 http://dx.doi.org/10.3390/molecules26040846 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nea, Fatimata
Bitchi, Michel Boni
Genva, Manon
Ledoux, Allison
Tchinda, Alembert Tiabou
Damblon, Christian
Frederich, Michel
Tonzibo, Zanahi Félix
Fauconnier, Marie-Laure
Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title_full Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title_fullStr Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title_full_unstemmed Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title_short Phytochemical Investigation and Biological Activities of Lantana rhodesiensis
title_sort phytochemical investigation and biological activities of lantana rhodesiensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915326/
https://www.ncbi.nlm.nih.gov/pubmed/33562771
http://dx.doi.org/10.3390/molecules26040846
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