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Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease

Background and Objectives: There is evidence that melatonin could improve the periodontal status and also glycemic control of patients with diabetes mellitus. Therefore, the aim of this study was to assess the effects of scaling and root planing plus adjunctive systemic treatment with melatonin on p...

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Autores principales: Anton, Diana-Maria, Martu, Maria-Alexandra, Maris, Marius, Maftei, George-Alexandru, Sufaru, Irina-Georgeta, Tatarciuc, Diana, Luchian, Ionut, Ioanid, Nicoleta, Martu, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915328/
https://www.ncbi.nlm.nih.gov/pubmed/33562452
http://dx.doi.org/10.3390/medicina57020140
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author Anton, Diana-Maria
Martu, Maria-Alexandra
Maris, Marius
Maftei, George-Alexandru
Sufaru, Irina-Georgeta
Tatarciuc, Diana
Luchian, Ionut
Ioanid, Nicoleta
Martu, Silvia
author_facet Anton, Diana-Maria
Martu, Maria-Alexandra
Maris, Marius
Maftei, George-Alexandru
Sufaru, Irina-Georgeta
Tatarciuc, Diana
Luchian, Ionut
Ioanid, Nicoleta
Martu, Silvia
author_sort Anton, Diana-Maria
collection PubMed
description Background and Objectives: There is evidence that melatonin could improve the periodontal status and also glycemic control of patients with diabetes mellitus. Therefore, the aim of this study was to assess the effects of scaling and root planing plus adjunctive systemic treatment with melatonin on periodontal parameters and glycemic control in patients with type 2 diabetes and chronic periodontitis. Materials and Methods: The study was conducted on 54 subjects with periodontitis and diabetes mellitus randomly assigned to the study group (n = 27, subjects with scaling and root planing + melatonin) or control group (n = 27, subjects with scaling and root planing + placebo). Periodontal parameters (probing depth—PD; clinical attachment loss—CAL; bleeding on probing—BOP; and hygiene level) and glycated hemoglobin (HbA1c) were assessed at baseline and 8 weeks after. Results: At baseline, there were no significant differences between groups, but at the second evaluation 8 weeks later the association of melatonin with the non-surgical periodontal therapy exerted statistically significant improvements, both in periodontal parameters, with a significant decrease in periodontal disease severity, and glycated hemoglobin when compared to the control subjects. Conclusions: In our study, combined non-surgical periodontal treatment and systemic treatment with melatonin provided additional improvements to severe periodontal condition and the glycemic control of patients with diabetes type 2 when compared to non-surgical periodontal treatment alone.
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spelling pubmed-79153282021-03-01 Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease Anton, Diana-Maria Martu, Maria-Alexandra Maris, Marius Maftei, George-Alexandru Sufaru, Irina-Georgeta Tatarciuc, Diana Luchian, Ionut Ioanid, Nicoleta Martu, Silvia Medicina (Kaunas) Article Background and Objectives: There is evidence that melatonin could improve the periodontal status and also glycemic control of patients with diabetes mellitus. Therefore, the aim of this study was to assess the effects of scaling and root planing plus adjunctive systemic treatment with melatonin on periodontal parameters and glycemic control in patients with type 2 diabetes and chronic periodontitis. Materials and Methods: The study was conducted on 54 subjects with periodontitis and diabetes mellitus randomly assigned to the study group (n = 27, subjects with scaling and root planing + melatonin) or control group (n = 27, subjects with scaling and root planing + placebo). Periodontal parameters (probing depth—PD; clinical attachment loss—CAL; bleeding on probing—BOP; and hygiene level) and glycated hemoglobin (HbA1c) were assessed at baseline and 8 weeks after. Results: At baseline, there were no significant differences between groups, but at the second evaluation 8 weeks later the association of melatonin with the non-surgical periodontal therapy exerted statistically significant improvements, both in periodontal parameters, with a significant decrease in periodontal disease severity, and glycated hemoglobin when compared to the control subjects. Conclusions: In our study, combined non-surgical periodontal treatment and systemic treatment with melatonin provided additional improvements to severe periodontal condition and the glycemic control of patients with diabetes type 2 when compared to non-surgical periodontal treatment alone. MDPI 2021-02-05 /pmc/articles/PMC7915328/ /pubmed/33562452 http://dx.doi.org/10.3390/medicina57020140 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Anton, Diana-Maria
Martu, Maria-Alexandra
Maris, Marius
Maftei, George-Alexandru
Sufaru, Irina-Georgeta
Tatarciuc, Diana
Luchian, Ionut
Ioanid, Nicoleta
Martu, Silvia
Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title_full Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title_fullStr Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title_full_unstemmed Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title_short Study on the Effects of Melatonin on Glycemic Control and Periodontal Parameters in Patients with Type II Diabetes Mellitus and Periodontal Disease
title_sort study on the effects of melatonin on glycemic control and periodontal parameters in patients with type ii diabetes mellitus and periodontal disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915328/
https://www.ncbi.nlm.nih.gov/pubmed/33562452
http://dx.doi.org/10.3390/medicina57020140
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