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Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?

Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to c...

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Autores principales: Bastian, Paulina, Dulski, Jaroslaw, Roszmann, Anna, Jacewicz, Dagmara, Kuban-Jankowska, Alicja, Slawek, Jaroslaw, Wozniak, Michal, Gorska-Ponikowska, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915370/
https://www.ncbi.nlm.nih.gov/pubmed/33562035
http://dx.doi.org/10.3390/antiox10020248
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author Bastian, Paulina
Dulski, Jaroslaw
Roszmann, Anna
Jacewicz, Dagmara
Kuban-Jankowska, Alicja
Slawek, Jaroslaw
Wozniak, Michal
Gorska-Ponikowska, Magdalena
author_facet Bastian, Paulina
Dulski, Jaroslaw
Roszmann, Anna
Jacewicz, Dagmara
Kuban-Jankowska, Alicja
Slawek, Jaroslaw
Wozniak, Michal
Gorska-Ponikowska, Magdalena
author_sort Bastian, Paulina
collection PubMed
description Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic needs of the cell. There are multiple data suggesting that disturbed mitochondrial homeostasis can lead to Parkinson’s disease (PD) development. 2-methoxyestradiol (2-ME), metabolite of 17β-estradiol (E2) and potential anticancer agent, was demonstrated to inhibit cell growth of hippocampal HT22 cells by means of nitric oxide synthase (NOS) production and oxidative stress at both pharmacologically and also physiologically relevant concentrations. Moreover, 2-ME was suggested to inhibit mitochondrial biogenesis and to be a dynamic regulator. This review is a comprehensive discussion, from both scientific and clinical point of view, about the influence of 2-ME on mitochondria and its plausible role as a modulator of neuron survival.
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spelling pubmed-79153702021-03-01 Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece? Bastian, Paulina Dulski, Jaroslaw Roszmann, Anna Jacewicz, Dagmara Kuban-Jankowska, Alicja Slawek, Jaroslaw Wozniak, Michal Gorska-Ponikowska, Magdalena Antioxidants (Basel) Review Mitochondria, as “power house of the cell”, are crucial players in cell pathophysiology. Beyond adenosine triphosphate (ATP) production, they take part in a generation of reactive oxygen species (ROS), regulation of cell signaling and cell death. Dysregulation of mitochondrial dynamics may lead to cancers and neurodegeneration; however, the fusion/fission cycle allows mitochondria to adapt to metabolic needs of the cell. There are multiple data suggesting that disturbed mitochondrial homeostasis can lead to Parkinson’s disease (PD) development. 2-methoxyestradiol (2-ME), metabolite of 17β-estradiol (E2) and potential anticancer agent, was demonstrated to inhibit cell growth of hippocampal HT22 cells by means of nitric oxide synthase (NOS) production and oxidative stress at both pharmacologically and also physiologically relevant concentrations. Moreover, 2-ME was suggested to inhibit mitochondrial biogenesis and to be a dynamic regulator. This review is a comprehensive discussion, from both scientific and clinical point of view, about the influence of 2-ME on mitochondria and its plausible role as a modulator of neuron survival. MDPI 2021-02-06 /pmc/articles/PMC7915370/ /pubmed/33562035 http://dx.doi.org/10.3390/antiox10020248 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bastian, Paulina
Dulski, Jaroslaw
Roszmann, Anna
Jacewicz, Dagmara
Kuban-Jankowska, Alicja
Slawek, Jaroslaw
Wozniak, Michal
Gorska-Ponikowska, Magdalena
Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title_full Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title_fullStr Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title_full_unstemmed Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title_short Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?
title_sort regulation of mitochondrial dynamics in parkinson’s disease—is 2-methoxyestradiol a missing piece?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915370/
https://www.ncbi.nlm.nih.gov/pubmed/33562035
http://dx.doi.org/10.3390/antiox10020248
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