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Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives

Recently, infectious diseases caused by bacterial pathogens have become a major cause of morbidity and mortality globally due to their resistance to multiple antibiotics. This has triggered initiatives to develop novel, alternative antimicrobial materials, which solve the issue of infection with mul...

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Detalles Bibliográficos
Autores principales: Basavegowda, Nagaraj, Baek, Kwang-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915418/
https://www.ncbi.nlm.nih.gov/pubmed/33572219
http://dx.doi.org/10.3390/molecules26040912
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author Basavegowda, Nagaraj
Baek, Kwang-Hyun
author_facet Basavegowda, Nagaraj
Baek, Kwang-Hyun
author_sort Basavegowda, Nagaraj
collection PubMed
description Recently, infectious diseases caused by bacterial pathogens have become a major cause of morbidity and mortality globally due to their resistance to multiple antibiotics. This has triggered initiatives to develop novel, alternative antimicrobial materials, which solve the issue of infection with multidrug-resistant bacteria. Nanotechnology using nanoscale materials, especially multimetallic nanoparticles (NPs), has attracted interest because of the favorable physicochemical properties of these materials, including antibacterial properties and excellent biocompatibility. Multimetallic NPs, particularly those formed by more than two metals, exhibit rich electronic, optical, and magnetic properties. Multimetallic NP properties, including size and shape, zeta potential, and large surface area, facilitate their efficient interaction with bacterial cell membranes, thereby inducing disruption, reactive oxygen species production, protein dysfunction, DNA damage, and killing potentiated by the host’s immune system. In this review, we summarize research progress on the synergistic effect of multimetallic NPs as alternative antimicrobial agents for treating severe bacterial infections. We highlight recent promising innovations of multimetallic NPs that help overcome antimicrobial resistance. These include insights into their properties, mode of action, the development of synthetic methods, and combinatorial therapies using bi- and trimetallic NPs with other existing antimicrobial agents.
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spelling pubmed-79154182021-03-01 Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives Basavegowda, Nagaraj Baek, Kwang-Hyun Molecules Review Recently, infectious diseases caused by bacterial pathogens have become a major cause of morbidity and mortality globally due to their resistance to multiple antibiotics. This has triggered initiatives to develop novel, alternative antimicrobial materials, which solve the issue of infection with multidrug-resistant bacteria. Nanotechnology using nanoscale materials, especially multimetallic nanoparticles (NPs), has attracted interest because of the favorable physicochemical properties of these materials, including antibacterial properties and excellent biocompatibility. Multimetallic NPs, particularly those formed by more than two metals, exhibit rich electronic, optical, and magnetic properties. Multimetallic NP properties, including size and shape, zeta potential, and large surface area, facilitate their efficient interaction with bacterial cell membranes, thereby inducing disruption, reactive oxygen species production, protein dysfunction, DNA damage, and killing potentiated by the host’s immune system. In this review, we summarize research progress on the synergistic effect of multimetallic NPs as alternative antimicrobial agents for treating severe bacterial infections. We highlight recent promising innovations of multimetallic NPs that help overcome antimicrobial resistance. These include insights into their properties, mode of action, the development of synthetic methods, and combinatorial therapies using bi- and trimetallic NPs with other existing antimicrobial agents. MDPI 2021-02-09 /pmc/articles/PMC7915418/ /pubmed/33572219 http://dx.doi.org/10.3390/molecules26040912 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Basavegowda, Nagaraj
Baek, Kwang-Hyun
Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title_full Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title_fullStr Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title_full_unstemmed Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title_short Multimetallic Nanoparticles as Alternative Antimicrobial Agents: Challenges and Perspectives
title_sort multimetallic nanoparticles as alternative antimicrobial agents: challenges and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915418/
https://www.ncbi.nlm.nih.gov/pubmed/33572219
http://dx.doi.org/10.3390/molecules26040912
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