Cargando…

Geniposide Improves Diabetic Nephropathy by Enhancing ULK1-Mediated Autophagy and Reducing Oxidative Stress through AMPK Activation

Diabetic nephropathy (DN) is a common pathological feature in patients with diabetes and the leading cause of end-stage renal disease. Although several pharmacological agents have been developed, the management of DN remains challenging. Geniposide, a natural compound has been reported for anti-infl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dusabimana, Theodomir, Park, Eun Jung, Je, Jihyun, Jeong, Kyuho, Yun, Seung Pil, Kim, Hye Jung, Kim, Hwajin, Park, Sang Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915505/ https://www.ncbi.nlm.nih.gov/pubmed/33562139 http://dx.doi.org/10.3390/ijms22041651

Ejemplares similares

P2Y2R contributes to the development of diabetic nephropathy by inhibiting autophagy response
por: Dusabimana, Theodomir, et al.
Publicado: (2020)

P2Y2R Deficiency Ameliorates Hepatic Steatosis by Reducing Lipogenesis and Enhancing Fatty Acid β-Oxidation through AMPK and PGC-1α Induction in High-Fat Diet-Fed Mice
por: Dusabimana, Theodomir, et al.
Publicado: (2021)

Supplementation of Abelmoschus manihot Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice
por: Kim, Hwajin, et al.
Publicado: (2018)

Honokiol Protects the Kidney from Renal Ischemia and Reperfusion Injury by Upregulating the Glutathione Biosynthetic Enzymes
por: Park, Eun Jung, et al.
Publicado: (2020)

Early Growth Response 1 Contributes to Renal IR Injury by Inducing Proximal Tubular Cell Apoptosis
por: Jeong, Kyuho, et al.
Publicado: (2023)

GOLPH3 promotes endotoxemia-induced liver and kidney injury through Golgi stress-mediated apoptosis and inflammatory response
por: Dusabimana, Theodomir, et al.
Publicado: (2023)

The Uremic Toxin Homocysteine Exacerbates the Brain Inflammation Induced by Renal Ischemia-Reperfusion in Mice
por: Park, Eun Jung, et al.
Publicado: (2022)

Mineralocorticoid Receptor Antagonism Attenuates Multiple Organ Failure after Renal Ischemia and Reperfusion in Mice
por: Park, Eun Jung, et al.
Publicado: (2023)

Platycodon grandiflorus Fermented Extracts Attenuate Endotoxin-Induced Acute Liver Injury in Mice
por: Kim, So Ra, et al.
Publicado: (2020)

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis
por: Dusabimana, Theodomir, et al.
Publicado: (2019)

The Association of AMPK with ULK1 Regulates Autophagy
por: Lee, Jong Woo, et al.
Publicado: (2010)

The proximal tubular α7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction
por: Kim, Hwajin, et al.
Publicado: (2018)

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
por: Dite, Toby A., et al.
Publicado: (2017)

GSK3B induces autophagy by phosphorylating ULK1
por: Ryu, Hye Young, et al.
Publicado: (2021)

Tangshen Decoction Enhances Podocytes Autophagy to Relieve Diabetic Nephropathy through Modulation of p-AMPK/p-ULK1 Signaling
por: Yan, Ling, et al.
Publicado: (2022)

Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation
por: Lee, Bina, et al.
Publicado: (2022)

Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway
por: Wang, Jiwei, et al.
Publicado: (2016)

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection
por: Fan, Xue-Yu, et al.
Publicado: (2015)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Osteogenic Differentiation by Modulating AMPK/ULK1‐Dependent Autophagy
por: Li, Zheng, et al.
Publicado: (2019)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

STAT3 suppresses the AMPKα/ULK1‐dependent induction of autophagy in glioblastoma cells
por: Bhattacharya, Sujoy, et al.
Publicado: (2022)

Globular Adiponectin Inhibits Lipopolysaccharide-Primed Inflammasomes Activation in Macrophages via Autophagy Induction: The Critical Role of AMPK Signaling
por: Kim, Mi Jin, et al.
Publicado: (2017)

Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
por: Yuan, Jie, et al.
Publicado: (2018)

AMPK/Ulk1-dependent autophagy as a key mTOR regulator in the context of cell pluripotency
por: Suvorova, Irina I., et al.
Publicado: (2019)

Fine-tuning of AMPK–ULK1–mTORC1 regulatory triangle is crucial for autophagy oscillation
por: Holczer, Marianna, et al.
Publicado: (2020)

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway
por: Ma, Teng, et al.
Publicado: (2022)

Systemic and molecular analysis dissect the red ginseng induction of apoptosis and autophagy in HCC as mediated with AMPK
por: Kim, Young Woo, et al.
Publicado: (2023)

Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX
por: Lee, Geum-Hwa, et al.
Publicado: (2014)

Salvia chinensia Benth induces autophagy in esophageal cancer cells via AMPK/ULK1 signaling pathway
por: Jia, Lei, et al.
Publicado: (2022)

Protection against Doxorubicin-Induced Cytotoxicity by Geniposide Involves AMPKα Signaling Pathway
por: Meng, Yan-Yan, et al.
Publicado: (2019)

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy
por: Lim, Ji Hee, et al.
Publicado: (2018)

Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling
por: Lin, Chenchu, et al.
Publicado: (2021)

Ebastine exerts antitumor activity and induces autophagy by activating AMPK/ULK1 signaling in an IPMK-dependent manner in osteosarcoma
por: Pan, Zhen, et al.
Publicado: (2023)

Ethyl Pyruvate Directly Attenuates Active Secretion of HMGB1 in Proximal Tubular Cells via Induction of Heme Oxygenase-1
por: Seo, Min Suk, et al.
Publicado: (2019)

Protective properties of geniposide against UV-B-induced photooxidative stress in human dermal fibroblasts
por: Shin, Daehyun, et al.
Publicado: (2018)

Redefining the role of AMPK in autophagy and the energy stress response
por: Park, Ji-Man, et al.
Publicado: (2023)

The mammalian ULK1 complex and autophagy initiation
por: Zachari, Maria, et al.
Publicado: (2017)

Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy
por: Li, Jingyi, et al.
Publicado: (2022)

ULK1 forms distinct oligomeric states and nanoscopic structures during autophagy initiation
por: Banerjee, Chiranjib, et al.
Publicado: (2023)

Lipopolysaccharide-Induced Dephosphorylation of AMPK-Activated Protein Kinase Potentiates Inflammatory Injury via Repression of ULK1-Dependent Autophagy
por: Fan, Kerui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iqbdas3i9c5knrtcgomp0rbu46