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Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatm...

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Autores principales: Lardinois, Benjamin, Favresse, Julien, Chatelain, Bernard, Lippi, Giuseppe, Mullier, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915523/
https://www.ncbi.nlm.nih.gov/pubmed/33557431
http://dx.doi.org/10.3390/jcm10040594
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author Lardinois, Benjamin
Favresse, Julien
Chatelain, Bernard
Lippi, Giuseppe
Mullier, François
author_facet Lardinois, Benjamin
Favresse, Julien
Chatelain, Bernard
Lippi, Giuseppe
Mullier, François
author_sort Lardinois, Benjamin
collection PubMed
description Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts.
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spelling pubmed-79155232021-03-01 Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications Lardinois, Benjamin Favresse, Julien Chatelain, Bernard Lippi, Giuseppe Mullier, François J Clin Med Review Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts. MDPI 2021-02-04 /pmc/articles/PMC7915523/ /pubmed/33557431 http://dx.doi.org/10.3390/jcm10040594 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lardinois, Benjamin
Favresse, Julien
Chatelain, Bernard
Lippi, Giuseppe
Mullier, François
Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title_full Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title_fullStr Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title_full_unstemmed Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title_short Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications
title_sort pseudothrombocytopenia—a review on causes, occurrence and clinical implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915523/
https://www.ncbi.nlm.nih.gov/pubmed/33557431
http://dx.doi.org/10.3390/jcm10040594
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