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Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development

Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A major contributing factor to this resistance is the presence of cancer stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs,...

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Detalles Bibliográficos
Autores principales: Hwang, Ga-Ram, Yuen, John G., Ju, Jingfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915611/
https://www.ncbi.nlm.nih.gov/pubmed/33562727
http://dx.doi.org/10.3390/ijms22041624
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author Hwang, Ga-Ram
Yuen, John G.
Ju, Jingfang
author_facet Hwang, Ga-Ram
Yuen, John G.
Ju, Jingfang
author_sort Hwang, Ga-Ram
collection PubMed
description Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A major contributing factor to this resistance is the presence of cancer stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found to regulate several key targets that are responsible for cancer stemness, and function as oncogenic miRNAs (oncomiRs) or tumor suppressor miRNAs. As a result, several miRNAs have been found to alter, or be altered by, the expression of CSC-defining markers and their related pathways. These miRNAs can be utilized to affect stemness in multiple ways, including directly targeting CSCs and enhancing the efficacy of cancer therapeutics. This review highlights current studies regarding the roles of miRNAs in GI CSCs, and efforts towards the development of cancer therapeutics.
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spelling pubmed-79156112021-03-01 Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development Hwang, Ga-Ram Yuen, John G. Ju, Jingfang Int J Mol Sci Review Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A major contributing factor to this resistance is the presence of cancer stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found to regulate several key targets that are responsible for cancer stemness, and function as oncogenic miRNAs (oncomiRs) or tumor suppressor miRNAs. As a result, several miRNAs have been found to alter, or be altered by, the expression of CSC-defining markers and their related pathways. These miRNAs can be utilized to affect stemness in multiple ways, including directly targeting CSCs and enhancing the efficacy of cancer therapeutics. This review highlights current studies regarding the roles of miRNAs in GI CSCs, and efforts towards the development of cancer therapeutics. MDPI 2021-02-05 /pmc/articles/PMC7915611/ /pubmed/33562727 http://dx.doi.org/10.3390/ijms22041624 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hwang, Ga-Ram
Yuen, John G.
Ju, Jingfang
Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title_full Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title_fullStr Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title_full_unstemmed Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title_short Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development
title_sort roles of micrornas in gastrointestinal cancer stem cell resistance and therapeutic development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915611/
https://www.ncbi.nlm.nih.gov/pubmed/33562727
http://dx.doi.org/10.3390/ijms22041624
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