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Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders

The clinical failure rate for disease-modifying treatments (DMTs) that slow or stop disease progression has been nearly 100% for the major neurodegenerative disorders (NDDs), with many compounds failing in expensive and time-consuming phase 2 and 3 trials for lack of efficacy. Here, we critically re...

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Detalles Bibliográficos
Autores principales:	Vissers, Maurits F. J. M., Heuberger, Jules A. A. C., Groeneveld, Geert Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915613/ https://www.ncbi.nlm.nih.gov/pubmed/33562713 http://dx.doi.org/10.3390/ijms22041615

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