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Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders
Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915700/ https://www.ncbi.nlm.nih.gov/pubmed/33562030 http://dx.doi.org/10.3390/molecules26040856 |
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author | Giordo, Roberta Zinellu, Angelo Eid, Ali Hussein Pintus, Gianfranco |
author_facet | Giordo, Roberta Zinellu, Angelo Eid, Ali Hussein Pintus, Gianfranco |
author_sort | Giordo, Roberta |
collection | PubMed |
description | Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal coagulation parameters in COVID-19 patients. Although treatments with low molecular weight heparin (LMWH) have shown beneficial effects in decreasing patient mortality with severe COVID-19, additional therapeutic strategies are urgently needed. Utilizing the anti-inflammatory and anti-thrombotic properties of natural compounds may provide alternative therapeutic approaches to prevent or reduce the risk factors associated with pre-existing conditions and comorbidities that can worsen COVID-19 patients’ outcomes. In this regard, resveratrol, a natural compound found in several plants and fruits such as grapes, blueberries and cranberries, may represent a promising coadjuvant for the prevention and treatment of COVID-19. By virtue of its anti-thrombotic and anti-inflammatory properties, resveratrol would be expected to lower COVID-19-associated mortality, which is well known to be increased by thrombosis and inflammation. This review analyzes and discusses resveratrol’s ability to modulate vascular hemostasis at different levels targeting both primary hemostasis (interfering with platelet activation and aggregation) and secondary hemostasis (modulating factors involved in coagulation cascade). |
format | Online Article Text |
id | pubmed-7915700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79157002021-03-01 Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders Giordo, Roberta Zinellu, Angelo Eid, Ali Hussein Pintus, Gianfranco Molecules Review Coagulation disorders, endotheliopathy and inflammation are the most common hallmarks in SARS-CoV-2 infection, largely determining COVID-19’s outcome and severity. Dysfunctions of endothelial cells and platelets are tightly linked in contributing to the systemic inflammatory response that appears to be both a cause and a consequence of COVID-19-associated coagulation disorders and thrombotic events. Indeed, elevated levels of circulating inflammatory cytokines are often associated with abnormal coagulation parameters in COVID-19 patients. Although treatments with low molecular weight heparin (LMWH) have shown beneficial effects in decreasing patient mortality with severe COVID-19, additional therapeutic strategies are urgently needed. Utilizing the anti-inflammatory and anti-thrombotic properties of natural compounds may provide alternative therapeutic approaches to prevent or reduce the risk factors associated with pre-existing conditions and comorbidities that can worsen COVID-19 patients’ outcomes. In this regard, resveratrol, a natural compound found in several plants and fruits such as grapes, blueberries and cranberries, may represent a promising coadjuvant for the prevention and treatment of COVID-19. By virtue of its anti-thrombotic and anti-inflammatory properties, resveratrol would be expected to lower COVID-19-associated mortality, which is well known to be increased by thrombosis and inflammation. This review analyzes and discusses resveratrol’s ability to modulate vascular hemostasis at different levels targeting both primary hemostasis (interfering with platelet activation and aggregation) and secondary hemostasis (modulating factors involved in coagulation cascade). MDPI 2021-02-06 /pmc/articles/PMC7915700/ /pubmed/33562030 http://dx.doi.org/10.3390/molecules26040856 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Giordo, Roberta Zinellu, Angelo Eid, Ali Hussein Pintus, Gianfranco Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title | Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title_full | Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title_fullStr | Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title_full_unstemmed | Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title_short | Therapeutic Potential of Resveratrol in COVID-19-Associated Hemostatic Disorders |
title_sort | therapeutic potential of resveratrol in covid-19-associated hemostatic disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915700/ https://www.ncbi.nlm.nih.gov/pubmed/33562030 http://dx.doi.org/10.3390/molecules26040856 |
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