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Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer

A combined transrectal ultrasound and photoacoustic (TRUS–PA) imaging probe was developed for the clear visualization of morphological changes and microvasculature distribution in the prostate, as this is required for accurate diagnosis and biopsy. The probe consisted of a miniaturized 128-element 7...

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Autores principales: Jang, Jihun, Kim, Jinwoo, Lee, Hak Jong, Chang, Jin Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915711/
https://www.ncbi.nlm.nih.gov/pubmed/33572287
http://dx.doi.org/10.3390/s21041217
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author Jang, Jihun
Kim, Jinwoo
Lee, Hak Jong
Chang, Jin Ho
author_facet Jang, Jihun
Kim, Jinwoo
Lee, Hak Jong
Chang, Jin Ho
author_sort Jang, Jihun
collection PubMed
description A combined transrectal ultrasound and photoacoustic (TRUS–PA) imaging probe was developed for the clear visualization of morphological changes and microvasculature distribution in the prostate, as this is required for accurate diagnosis and biopsy. The probe consisted of a miniaturized 128-element 7 MHz convex array transducer with 134.5° field-of-view (FOV), a bifurcated optical fiber bundle, and two optical lenses. The design goal was to make the size of the TRUS–PA probe similar to that of general TRUS probes (i.e., about 20 mm), for the convenience of the patients. New flexible printed circuit board (FPCB), acoustic structure, and optical lens were developed to meet the requirement of the probe size, as well as to realize a high-performance TRUS–PA probe. In visual assessment, the PA signals obtained with the optical lens were 2.98 times higher than those without the lens. Moreover, the in vivo experiment with the xenograft BALB/c (Albino, Immunodeficient Inbred Strain) mouse model showed that TRUS–PA probe was able to acquire the entire PA image of the mouse tight behind the porcine intestine about 25 mm depth. From the ex vivo and in vivo experimental results, it can be concluded that the developed TRUS–PA probe is capable of improving PA image quality, even though the TRUS–PA probe has a cross-section size and an FOV comparable to those of general TRUS probes.
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spelling pubmed-79157112021-03-01 Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer Jang, Jihun Kim, Jinwoo Lee, Hak Jong Chang, Jin Ho Sensors (Basel) Article A combined transrectal ultrasound and photoacoustic (TRUS–PA) imaging probe was developed for the clear visualization of morphological changes and microvasculature distribution in the prostate, as this is required for accurate diagnosis and biopsy. The probe consisted of a miniaturized 128-element 7 MHz convex array transducer with 134.5° field-of-view (FOV), a bifurcated optical fiber bundle, and two optical lenses. The design goal was to make the size of the TRUS–PA probe similar to that of general TRUS probes (i.e., about 20 mm), for the convenience of the patients. New flexible printed circuit board (FPCB), acoustic structure, and optical lens were developed to meet the requirement of the probe size, as well as to realize a high-performance TRUS–PA probe. In visual assessment, the PA signals obtained with the optical lens were 2.98 times higher than those without the lens. Moreover, the in vivo experiment with the xenograft BALB/c (Albino, Immunodeficient Inbred Strain) mouse model showed that TRUS–PA probe was able to acquire the entire PA image of the mouse tight behind the porcine intestine about 25 mm depth. From the ex vivo and in vivo experimental results, it can be concluded that the developed TRUS–PA probe is capable of improving PA image quality, even though the TRUS–PA probe has a cross-section size and an FOV comparable to those of general TRUS probes. MDPI 2021-02-09 /pmc/articles/PMC7915711/ /pubmed/33572287 http://dx.doi.org/10.3390/s21041217 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jang, Jihun
Kim, Jinwoo
Lee, Hak Jong
Chang, Jin Ho
Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title_full Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title_fullStr Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title_full_unstemmed Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title_short Transrectal Ultrasound and Photoacoustic Imaging Probe for Diagnosis of Prostate Cancer
title_sort transrectal ultrasound and photoacoustic imaging probe for diagnosis of prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915711/
https://www.ncbi.nlm.nih.gov/pubmed/33572287
http://dx.doi.org/10.3390/s21041217
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