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Proton Therapy for Mandibula Plate Phantom

Purpose: In this study, the required dose rates for optimal treatment of tumoral tissues when using proton therapy in the treatment of defective tumours seen in mandibles has been calculated. We aimed to protect the surrounding soft and hard tissues from unnecessary radiation as well as to prevent c...

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Autores principales: Senirkentli, Güler Burcu, Ekinci, Fatih, Bostanci, Erkan, Güzel, Mehmet Serdar, Dağli, Özlem, Karim, Ahmad M., Mishra, Alok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915841/
https://www.ncbi.nlm.nih.gov/pubmed/33557337
http://dx.doi.org/10.3390/healthcare9020167
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author Senirkentli, Güler Burcu
Ekinci, Fatih
Bostanci, Erkan
Güzel, Mehmet Serdar
Dağli, Özlem
Karim, Ahmad M.
Mishra, Alok
author_facet Senirkentli, Güler Burcu
Ekinci, Fatih
Bostanci, Erkan
Güzel, Mehmet Serdar
Dağli, Özlem
Karim, Ahmad M.
Mishra, Alok
author_sort Senirkentli, Güler Burcu
collection PubMed
description Purpose: In this study, the required dose rates for optimal treatment of tumoral tissues when using proton therapy in the treatment of defective tumours seen in mandibles has been calculated. We aimed to protect the surrounding soft and hard tissues from unnecessary radiation as well as to prevent complications of radiation. Bragg curves of therapeutic energized protons for two different mandible (molar and premolar) plate phantoms were computed and compared with similar calculations in the literature. The results were found to be within acceptable deviation values. Methods: In this study, mandibular tooth plate phantoms were modelled for the molar and premolar areas and then a Monte Carlo simulation was used to calculate the Bragg curve, lateral straggle/range and recoil values of protons remaining in the therapeutic energy ranges. The mass and atomic densities of all the jawbone layers were selected and the effect of layer type and thickness on the Bragg curve, lateral straggle/range and the recoil were investigated. As protons move through different layers of density, lateral straggle and increases in the range were observed. A range of energies was used for the treatment of tumours at different depths in the mandible phantom. Results: Simulations revealed that as the cortical bone thickness increased, Bragg peak position decreased between 0.47–3.3%. An increase in the number of layers results in a decrease in the Bragg peak position. Finally, as the proton energy increased, the amplitude of the second peak and its effect on Bragg peak position decreased. Conclusion: These findings should guide the selection of appropriate energy levels in the treatment of tumour structures without damaging surrounding tissues.
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spelling pubmed-79158412021-03-01 Proton Therapy for Mandibula Plate Phantom Senirkentli, Güler Burcu Ekinci, Fatih Bostanci, Erkan Güzel, Mehmet Serdar Dağli, Özlem Karim, Ahmad M. Mishra, Alok Healthcare (Basel) Article Purpose: In this study, the required dose rates for optimal treatment of tumoral tissues when using proton therapy in the treatment of defective tumours seen in mandibles has been calculated. We aimed to protect the surrounding soft and hard tissues from unnecessary radiation as well as to prevent complications of radiation. Bragg curves of therapeutic energized protons for two different mandible (molar and premolar) plate phantoms were computed and compared with similar calculations in the literature. The results were found to be within acceptable deviation values. Methods: In this study, mandibular tooth plate phantoms were modelled for the molar and premolar areas and then a Monte Carlo simulation was used to calculate the Bragg curve, lateral straggle/range and recoil values of protons remaining in the therapeutic energy ranges. The mass and atomic densities of all the jawbone layers were selected and the effect of layer type and thickness on the Bragg curve, lateral straggle/range and the recoil were investigated. As protons move through different layers of density, lateral straggle and increases in the range were observed. A range of energies was used for the treatment of tumours at different depths in the mandible phantom. Results: Simulations revealed that as the cortical bone thickness increased, Bragg peak position decreased between 0.47–3.3%. An increase in the number of layers results in a decrease in the Bragg peak position. Finally, as the proton energy increased, the amplitude of the second peak and its effect on Bragg peak position decreased. Conclusion: These findings should guide the selection of appropriate energy levels in the treatment of tumour structures without damaging surrounding tissues. MDPI 2021-02-04 /pmc/articles/PMC7915841/ /pubmed/33557337 http://dx.doi.org/10.3390/healthcare9020167 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Senirkentli, Güler Burcu
Ekinci, Fatih
Bostanci, Erkan
Güzel, Mehmet Serdar
Dağli, Özlem
Karim, Ahmad M.
Mishra, Alok
Proton Therapy for Mandibula Plate Phantom
title Proton Therapy for Mandibula Plate Phantom
title_full Proton Therapy for Mandibula Plate Phantom
title_fullStr Proton Therapy for Mandibula Plate Phantom
title_full_unstemmed Proton Therapy for Mandibula Plate Phantom
title_short Proton Therapy for Mandibula Plate Phantom
title_sort proton therapy for mandibula plate phantom
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915841/
https://www.ncbi.nlm.nih.gov/pubmed/33557337
http://dx.doi.org/10.3390/healthcare9020167
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