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Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression

The role that thyroid hormone deficiency plays in depression and synaptic plasticity in adults has only begun to be elucidated. This paper analyzes the possible link between depression and hypothyroidism in cognitive function alterations, using Wistar–Kyoto (WKY—an animal model of depression) rats a...

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Autores principales: Głombik, Katarzyna, Detka, Jan, Bobula, Bartosz, Bąk, Joanna, Kusek, Magdalena, Tokarski, Krzysztof, Budziszewska, Bogusława
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915890/
https://www.ncbi.nlm.nih.gov/pubmed/33562494
http://dx.doi.org/10.3390/ijms22041599
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author Głombik, Katarzyna
Detka, Jan
Bobula, Bartosz
Bąk, Joanna
Kusek, Magdalena
Tokarski, Krzysztof
Budziszewska, Bogusława
author_facet Głombik, Katarzyna
Detka, Jan
Bobula, Bartosz
Bąk, Joanna
Kusek, Magdalena
Tokarski, Krzysztof
Budziszewska, Bogusława
author_sort Głombik, Katarzyna
collection PubMed
description The role that thyroid hormone deficiency plays in depression and synaptic plasticity in adults has only begun to be elucidated. This paper analyzes the possible link between depression and hypothyroidism in cognitive function alterations, using Wistar–Kyoto (WKY—an animal model of depression) rats and control Wistar rats under standard and thyroid hormone deficiency conditions (propylthiouracil administration—PTU). A weakening of memory processes in the WKY rats is shown behaviorally, and in the reduction of long-term potentiation (LTP) in the dentate gyrus (DG) and CA1 hippocampal regions. PTU administration decreased LTP and increased basal excitatory transmission in the DG in Wistar rats. A decrease in short-term synaptic plasticity is shown by the paired-pulse ratio measurement, occurring during hypothyroidism in DG and CA1 in WKY rats. Differences between the strains may result from decreases in the p-CaMKII, p-AKT, and the level of acetylcholine, while in the case of the co-occurrence of depression and hypothyroidism, an increase in the p-ERK1-MAP seemed to be important. Obtained results show that thyroid hormones are less involved in the inhibition of glutamate release and/or excitability of the postsynaptic neurons in WKY rats, which may indicate a lower sensitivity of the hippocampus to the action of thyroid hormones in depression.
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spelling pubmed-79158902021-03-01 Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression Głombik, Katarzyna Detka, Jan Bobula, Bartosz Bąk, Joanna Kusek, Magdalena Tokarski, Krzysztof Budziszewska, Bogusława Int J Mol Sci Article The role that thyroid hormone deficiency plays in depression and synaptic plasticity in adults has only begun to be elucidated. This paper analyzes the possible link between depression and hypothyroidism in cognitive function alterations, using Wistar–Kyoto (WKY—an animal model of depression) rats and control Wistar rats under standard and thyroid hormone deficiency conditions (propylthiouracil administration—PTU). A weakening of memory processes in the WKY rats is shown behaviorally, and in the reduction of long-term potentiation (LTP) in the dentate gyrus (DG) and CA1 hippocampal regions. PTU administration decreased LTP and increased basal excitatory transmission in the DG in Wistar rats. A decrease in short-term synaptic plasticity is shown by the paired-pulse ratio measurement, occurring during hypothyroidism in DG and CA1 in WKY rats. Differences between the strains may result from decreases in the p-CaMKII, p-AKT, and the level of acetylcholine, while in the case of the co-occurrence of depression and hypothyroidism, an increase in the p-ERK1-MAP seemed to be important. Obtained results show that thyroid hormones are less involved in the inhibition of glutamate release and/or excitability of the postsynaptic neurons in WKY rats, which may indicate a lower sensitivity of the hippocampus to the action of thyroid hormones in depression. MDPI 2021-02-05 /pmc/articles/PMC7915890/ /pubmed/33562494 http://dx.doi.org/10.3390/ijms22041599 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Głombik, Katarzyna
Detka, Jan
Bobula, Bartosz
Bąk, Joanna
Kusek, Magdalena
Tokarski, Krzysztof
Budziszewska, Bogusława
Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title_full Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title_fullStr Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title_full_unstemmed Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title_short Contribution of Hypothyroidism to Cognitive Impairment and Hippocampal Synaptic Plasticity Regulation in an Animal Model of Depression
title_sort contribution of hypothyroidism to cognitive impairment and hippocampal synaptic plasticity regulation in an animal model of depression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915890/
https://www.ncbi.nlm.nih.gov/pubmed/33562494
http://dx.doi.org/10.3390/ijms22041599
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