HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells

HIV-1 infects T cells, but the most frequent AIDS-related lymphomas are of B-cell origin. Molecular mechanisms of HIV-1-induced oncogenic transformation of B cells remain largely unknown. HIV-1 Tat protein may participate in this process by penetrating and regulating gene expression in B cells. Both...

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Autores principales: Akbay, Burkitkan, Germini, Diego, Bissenbaev, Amangeldy K., Musinova, Yana R., Sheval, Evgeny V., Vassetzky, Yegor, Dokudovskaya, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7915967/
https://www.ncbi.nlm.nih.gov/pubmed/33557396
http://dx.doi.org/10.3390/ijms22041588

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