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The Key Role of Nucleic Acid Vaccines for One Health

The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the develo...

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Detalles Bibliográficos
Autores principales: Fomsgaard, Anders, Liu, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916035/
https://www.ncbi.nlm.nih.gov/pubmed/33567520
http://dx.doi.org/10.3390/v13020258
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author Fomsgaard, Anders
Liu, Margaret A.
author_facet Fomsgaard, Anders
Liu, Margaret A.
author_sort Fomsgaard, Anders
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description The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases.
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spelling pubmed-79160352021-03-01 The Key Role of Nucleic Acid Vaccines for One Health Fomsgaard, Anders Liu, Margaret A. Viruses Review The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases. MDPI 2021-02-08 /pmc/articles/PMC7916035/ /pubmed/33567520 http://dx.doi.org/10.3390/v13020258 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fomsgaard, Anders
Liu, Margaret A.
The Key Role of Nucleic Acid Vaccines for One Health
title The Key Role of Nucleic Acid Vaccines for One Health
title_full The Key Role of Nucleic Acid Vaccines for One Health
title_fullStr The Key Role of Nucleic Acid Vaccines for One Health
title_full_unstemmed The Key Role of Nucleic Acid Vaccines for One Health
title_short The Key Role of Nucleic Acid Vaccines for One Health
title_sort key role of nucleic acid vaccines for one health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916035/
https://www.ncbi.nlm.nih.gov/pubmed/33567520
http://dx.doi.org/10.3390/v13020258
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