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The Key Role of Nucleic Acid Vaccines for One Health
The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the develo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916035/ https://www.ncbi.nlm.nih.gov/pubmed/33567520 http://dx.doi.org/10.3390/v13020258 |
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author | Fomsgaard, Anders Liu, Margaret A. |
author_facet | Fomsgaard, Anders Liu, Margaret A. |
author_sort | Fomsgaard, Anders |
collection | PubMed |
description | The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases. |
format | Online Article Text |
id | pubmed-7916035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79160352021-03-01 The Key Role of Nucleic Acid Vaccines for One Health Fomsgaard, Anders Liu, Margaret A. Viruses Review The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases. MDPI 2021-02-08 /pmc/articles/PMC7916035/ /pubmed/33567520 http://dx.doi.org/10.3390/v13020258 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fomsgaard, Anders Liu, Margaret A. The Key Role of Nucleic Acid Vaccines for One Health |
title | The Key Role of Nucleic Acid Vaccines for One Health |
title_full | The Key Role of Nucleic Acid Vaccines for One Health |
title_fullStr | The Key Role of Nucleic Acid Vaccines for One Health |
title_full_unstemmed | The Key Role of Nucleic Acid Vaccines for One Health |
title_short | The Key Role of Nucleic Acid Vaccines for One Health |
title_sort | key role of nucleic acid vaccines for one health |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916035/ https://www.ncbi.nlm.nih.gov/pubmed/33567520 http://dx.doi.org/10.3390/v13020258 |
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