Cargando…
The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes
Background: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced surviv...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916068/ https://www.ncbi.nlm.nih.gov/pubmed/33557340 http://dx.doi.org/10.3390/nu13020514 |
_version_ | 1783657394633441280 |
---|---|
author | Harrowfield, Jane Isenring, Elizabeth Kiss, Nicole Laing, Erin Lipson-Smith, Ruby Britton, Ben |
author_facet | Harrowfield, Jane Isenring, Elizabeth Kiss, Nicole Laing, Erin Lipson-Smith, Ruby Britton, Ben |
author_sort | Harrowfield, Jane |
collection | PubMed |
description | Background: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced survival rate. Human papillomavirus (HPV) is now known as the major cause of OPSCC. However, research regarding its effect on nutritional outcomes is limited. The aim of this study was to examine the relationship between HPV status and nutritional outcomes, including malnutrition and weight loss during and after patients’ (chemo) radiotherapy treatment for OPSCC. Methods: This was a longitudinal cohort study comparing the nutritional outcomes of HPV-positive and negative OPSCC patients undergoing (chemo) radiotherapy. The primary outcome was nutritional status as measured using the Patient Generated-Subjective Global Assessment (PG-SGA). Secondary outcomes included loss of weight, depression, QOL and adverse events. Results: Although HPV-positive were less likely to be malnourished according to PG-SGA at the beginning of treatment, we found that the difference between malnutrition rates in response to treatment was not significantly different over the course of radiotherapy and 3 months post treatment. HPV-positive participants had significantly higher odds of experiencing >10% weight loss at three months post-treatment than HPV-negative participants (OR = 49.68, 95% CI (2.7, 912.86) p ≤ 0.01). Conclusions: The nutritional status of HPV positive and negative patients were both negatively affected by treatment and require similarly intense nutritional intervention. In acute recovery, HPV positive patients may require more intense intervention. At 3- months post treatment, both groups still showed nutritional symptoms that require nutritional intervention so ongoing nutritional support is essential. |
format | Online Article Text |
id | pubmed-7916068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79160682021-03-01 The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes Harrowfield, Jane Isenring, Elizabeth Kiss, Nicole Laing, Erin Lipson-Smith, Ruby Britton, Ben Nutrients Article Background: Patients undergoing (chemo) radiotherapy for oropharyngeal squamous cell carcinoma (OPSCC) are at high risk of malnutrition during and after treatment. Malnutrition can lead to poor tolerance to treatment, treatment interruptions, poor quality of life (QOL) and potentially reduced survival rate. Human papillomavirus (HPV) is now known as the major cause of OPSCC. However, research regarding its effect on nutritional outcomes is limited. The aim of this study was to examine the relationship between HPV status and nutritional outcomes, including malnutrition and weight loss during and after patients’ (chemo) radiotherapy treatment for OPSCC. Methods: This was a longitudinal cohort study comparing the nutritional outcomes of HPV-positive and negative OPSCC patients undergoing (chemo) radiotherapy. The primary outcome was nutritional status as measured using the Patient Generated-Subjective Global Assessment (PG-SGA). Secondary outcomes included loss of weight, depression, QOL and adverse events. Results: Although HPV-positive were less likely to be malnourished according to PG-SGA at the beginning of treatment, we found that the difference between malnutrition rates in response to treatment was not significantly different over the course of radiotherapy and 3 months post treatment. HPV-positive participants had significantly higher odds of experiencing >10% weight loss at three months post-treatment than HPV-negative participants (OR = 49.68, 95% CI (2.7, 912.86) p ≤ 0.01). Conclusions: The nutritional status of HPV positive and negative patients were both negatively affected by treatment and require similarly intense nutritional intervention. In acute recovery, HPV positive patients may require more intense intervention. At 3- months post treatment, both groups still showed nutritional symptoms that require nutritional intervention so ongoing nutritional support is essential. MDPI 2021-02-04 /pmc/articles/PMC7916068/ /pubmed/33557340 http://dx.doi.org/10.3390/nu13020514 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Harrowfield, Jane Isenring, Elizabeth Kiss, Nicole Laing, Erin Lipson-Smith, Ruby Britton, Ben The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title_full | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title_fullStr | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title_full_unstemmed | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title_short | The Impact of Human Papillomavirus (HPV) Associated Oropharyngeal Squamous Cell Carcinoma (OPSCC) on Nutritional Outcomes |
title_sort | impact of human papillomavirus (hpv) associated oropharyngeal squamous cell carcinoma (opscc) on nutritional outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916068/ https://www.ncbi.nlm.nih.gov/pubmed/33557340 http://dx.doi.org/10.3390/nu13020514 |
work_keys_str_mv | AT harrowfieldjane theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT isenringelizabeth theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT kissnicole theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT laingerin theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT lipsonsmithruby theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT brittonben theimpactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT harrowfieldjane impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT isenringelizabeth impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT kissnicole impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT laingerin impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT lipsonsmithruby impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes AT brittonben impactofhumanpapillomavirushpvassociatedoropharyngealsquamouscellcarcinomaopscconnutritionaloutcomes |