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Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study
Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adult...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916078/ https://www.ncbi.nlm.nih.gov/pubmed/33567505 http://dx.doi.org/10.3390/nu13020549 |
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author | Camacho-Barcia, Lucía García-Gavilán, Jesús Papandreou, Christopher Hansen, Thea T. Harrold, Jo A. Finlayson, Graham Blundell, John E. Sjödin, Anders Halford, Jason C. G. Bulló, Mònica |
author_facet | Camacho-Barcia, Lucía García-Gavilán, Jesús Papandreou, Christopher Hansen, Thea T. Harrold, Jo A. Finlayson, Graham Blundell, John E. Sjödin, Anders Halford, Jason C. G. Bulló, Mònica |
author_sort | Camacho-Barcia, Lucía |
collection | PubMed |
description | Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the “Satiety Innovation”-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson’s correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects. |
format | Online Article Text |
id | pubmed-7916078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79160782021-03-01 Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study Camacho-Barcia, Lucía García-Gavilán, Jesús Papandreou, Christopher Hansen, Thea T. Harrold, Jo A. Finlayson, Graham Blundell, John E. Sjödin, Anders Halford, Jason C. G. Bulló, Mònica Nutrients Article Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the “Satiety Innovation”-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson’s correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects. MDPI 2021-02-08 /pmc/articles/PMC7916078/ /pubmed/33567505 http://dx.doi.org/10.3390/nu13020549 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Camacho-Barcia, Lucía García-Gavilán, Jesús Papandreou, Christopher Hansen, Thea T. Harrold, Jo A. Finlayson, Graham Blundell, John E. Sjödin, Anders Halford, Jason C. G. Bulló, Mònica Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title | Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title_full | Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title_fullStr | Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title_full_unstemmed | Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title_short | Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study |
title_sort | circulating metabolites associated with postprandial satiety in overweight/obese participants: the satin study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916078/ https://www.ncbi.nlm.nih.gov/pubmed/33567505 http://dx.doi.org/10.3390/nu13020549 |
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