Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept

SIMPLE SUMMARY: (CAR)-T cell-based therapies have achieved substantial success against different haematological malignancies. However, results for solid tumours have been limited up to now, in part due to the fact that the immunosuppressive tumour microenvironment inactivates CAR-T cell clones. In t...

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Detalles Bibliográficos
Autores principales: León-Triana, Odelaisy, Pérez-Martínez, Antonio, Ramírez-Orellana, Manuel, Pérez-García, Víctor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916125/
https://www.ncbi.nlm.nih.gov/pubmed/33572301
http://dx.doi.org/10.3390/cancers13040703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916125/
https://www.ncbi.nlm.nih.gov/pubmed/33572301
http://dx.doi.org/10.3390/cancers13040703

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