Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor

Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reel...

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Autores principales: Dlugosz, Paula, Teufl, Magdalena, Schwab, Maximilian, Kohl, Katharina Eva, Nimpf, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916142/
https://www.ncbi.nlm.nih.gov/pubmed/33572344
http://dx.doi.org/10.3390/ijms22041745
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author Dlugosz, Paula
Teufl, Magdalena
Schwab, Maximilian
Kohl, Katharina Eva
Nimpf, Johannes
author_facet Dlugosz, Paula
Teufl, Magdalena
Schwab, Maximilian
Kohl, Katharina Eva
Nimpf, Johannes
author_sort Dlugosz, Paula
collection PubMed
description Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors.
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spelling pubmed-79161422021-03-01 Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor Dlugosz, Paula Teufl, Magdalena Schwab, Maximilian Kohl, Katharina Eva Nimpf, Johannes Int J Mol Sci Article Disabled 1 (Dab1) is an adapter protein for very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) and an integral component of the Reelin pathway which orchestrates neuronal layering during embryonic brain development. Activation of Dab1 is induced by binding of Reelin to ApoER2 and VLDLR and phosphorylation of Dab1 mediated by Src family kinases. Here we show that Dab1 also acts as an adaptor for epidermal growth factor receptor (EGFR) and can be phosphorylated by epidermal growth factor (EGF) binding to EGFR. Phosphorylation of Dab1 depends on the kinase activity of EGFR constituting a signal pathway independent of Reelin and its receptors. MDPI 2021-02-09 /pmc/articles/PMC7916142/ /pubmed/33572344 http://dx.doi.org/10.3390/ijms22041745 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dlugosz, Paula
Teufl, Magdalena
Schwab, Maximilian
Kohl, Katharina Eva
Nimpf, Johannes
Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title_full Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title_fullStr Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title_full_unstemmed Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title_short Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor
title_sort disabled 1 is part of a signaling pathway activated by epidermal growth factor receptor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916142/
https://www.ncbi.nlm.nih.gov/pubmed/33572344
http://dx.doi.org/10.3390/ijms22041745
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