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Bacteriophage-Derived Depolymerases against Bacterial Biofilm

In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological respons...

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Autores principales: Topka-Bielecka, Gracja, Dydecka, Aleksandra, Necel, Agnieszka, Bloch, Sylwia, Nejman-Faleńczyk, Bożena, Węgrzyn, Grzegorz, Węgrzyn, Alicja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916357/
https://www.ncbi.nlm.nih.gov/pubmed/33578658
http://dx.doi.org/10.3390/antibiotics10020175
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author Topka-Bielecka, Gracja
Dydecka, Aleksandra
Necel, Agnieszka
Bloch, Sylwia
Nejman-Faleńczyk, Bożena
Węgrzyn, Grzegorz
Węgrzyn, Alicja
author_facet Topka-Bielecka, Gracja
Dydecka, Aleksandra
Necel, Agnieszka
Bloch, Sylwia
Nejman-Faleńczyk, Bożena
Węgrzyn, Grzegorz
Węgrzyn, Alicja
author_sort Topka-Bielecka, Gracja
collection PubMed
description In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms.
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spelling pubmed-79163572021-03-01 Bacteriophage-Derived Depolymerases against Bacterial Biofilm Topka-Bielecka, Gracja Dydecka, Aleksandra Necel, Agnieszka Bloch, Sylwia Nejman-Faleńczyk, Bożena Węgrzyn, Grzegorz Węgrzyn, Alicja Antibiotics (Basel) Review In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms. MDPI 2021-02-10 /pmc/articles/PMC7916357/ /pubmed/33578658 http://dx.doi.org/10.3390/antibiotics10020175 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Topka-Bielecka, Gracja
Dydecka, Aleksandra
Necel, Agnieszka
Bloch, Sylwia
Nejman-Faleńczyk, Bożena
Węgrzyn, Grzegorz
Węgrzyn, Alicja
Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title_full Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title_fullStr Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title_full_unstemmed Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title_short Bacteriophage-Derived Depolymerases against Bacterial Biofilm
title_sort bacteriophage-derived depolymerases against bacterial biofilm
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916357/
https://www.ncbi.nlm.nih.gov/pubmed/33578658
http://dx.doi.org/10.3390/antibiotics10020175
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