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Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches

Mitochondria do not exist as individual entities in the cell—conversely, they constitute an interconnected community governed by the constant and opposite process of fission and fusion. The mitochondrial fission leads to the formation of smaller mitochondria, promoting the biogenesis of new organell...

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Autores principales: Di Nottia, Michela, Verrigni, Daniela, Torraco, Alessandra, Rizza, Teresa, Bertini, Enrico, Carrozzo, Rosalba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916359/
https://www.ncbi.nlm.nih.gov/pubmed/33578638
http://dx.doi.org/10.3390/genes12020247
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author Di Nottia, Michela
Verrigni, Daniela
Torraco, Alessandra
Rizza, Teresa
Bertini, Enrico
Carrozzo, Rosalba
author_facet Di Nottia, Michela
Verrigni, Daniela
Torraco, Alessandra
Rizza, Teresa
Bertini, Enrico
Carrozzo, Rosalba
author_sort Di Nottia, Michela
collection PubMed
description Mitochondria do not exist as individual entities in the cell—conversely, they constitute an interconnected community governed by the constant and opposite process of fission and fusion. The mitochondrial fission leads to the formation of smaller mitochondria, promoting the biogenesis of new organelles. On the other hand, following the fusion process, mitochondria appear as longer and interconnected tubules, which enhance the communication with other organelles. Both fission and fusion are carried out by a small number of highly conserved guanosine triphosphatase proteins and their interactors. Disruption of this equilibrium has been associated with several pathological conditions, ranging from cancer to neurodegeneration, and mutations in genes involved in mitochondrial fission and fusion have been reported to be the cause of a subset of neurogenetic disorders.
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spelling pubmed-79163592021-03-01 Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches Di Nottia, Michela Verrigni, Daniela Torraco, Alessandra Rizza, Teresa Bertini, Enrico Carrozzo, Rosalba Genes (Basel) Review Mitochondria do not exist as individual entities in the cell—conversely, they constitute an interconnected community governed by the constant and opposite process of fission and fusion. The mitochondrial fission leads to the formation of smaller mitochondria, promoting the biogenesis of new organelles. On the other hand, following the fusion process, mitochondria appear as longer and interconnected tubules, which enhance the communication with other organelles. Both fission and fusion are carried out by a small number of highly conserved guanosine triphosphatase proteins and their interactors. Disruption of this equilibrium has been associated with several pathological conditions, ranging from cancer to neurodegeneration, and mutations in genes involved in mitochondrial fission and fusion have been reported to be the cause of a subset of neurogenetic disorders. MDPI 2021-02-10 /pmc/articles/PMC7916359/ /pubmed/33578638 http://dx.doi.org/10.3390/genes12020247 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Nottia, Michela
Verrigni, Daniela
Torraco, Alessandra
Rizza, Teresa
Bertini, Enrico
Carrozzo, Rosalba
Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title_full Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title_fullStr Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title_full_unstemmed Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title_short Mitochondrial Dynamics: Molecular Mechanisms, Related Primary Mitochondrial Disorders and Therapeutic Approaches
title_sort mitochondrial dynamics: molecular mechanisms, related primary mitochondrial disorders and therapeutic approaches
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916359/
https://www.ncbi.nlm.nih.gov/pubmed/33578638
http://dx.doi.org/10.3390/genes12020247
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