Genetic Association Analysis for Relative Growths of Body Compositions and Metabolic Traits to Body Weights in Broilers

SIMPLE SUMMARY: The relative growth of body components and metabolic traits relative to body weights are phenotypically characterized using joint allometric scaling models, and random regression models (RRMs) are constructed to map quantitative trait loci (QTLs) for allometries of body compositions and metabolic traits in broilers. Prior to statistically inferring the QTLs for the allometric scalings, the QTL candidates in RRMs are obtained by rapidly shrinking most of marker genetic effects to zero with the LASSO technique. Referred to as real joint allometric scaling models, statistical utility of the so-called LASSO-RRM mapping method is demonstrated by computer simulation analysis. Using the F2 population by crossing broiler × Fayoumi, we formulate optimal joint allometric scaling models of fat, shank weight (shank-w) and liver as well as thyroxine (T4) and glucose (GLC) to body weights. For body compositions, a total of 9 QTLs, including 4 additive and 5 dominant, were detected to control the allometric scalings of fat, shank-w and liver to body weights; while for metabolic traits, total 10 QTLs, were mapped to govern the allometries of T4 and GLC to body weights, among which 6 QTLs were of dominant genetic effect. The detected QTLs or highly linked markers can be used to regulate relative growths for meat quality traits to body weight in marker-assisted breeding of broilers. ABSTRACT: In animal breeding, body components and metabolic traits always fall behind body weights in genetic improvement, which leads to the decline in standards and qualities of animal products. Phenotypically, the relative growth of multiple body components and metabolic traits relative to body weights are characterized by using joint allometric scaling models, and then random regression models (RRMs) are constructed to map quantitative trait loci (QTLs) for relative grwoth allometries of body compositions and metabolic traits in chicken. Referred to as real joint allometric scaling models, statistical utility of the so-called LASSO-RRM mapping method is given a demonstration by computer simulation analysis. Using the F2 population by crossing broiler × Fayoumi, we formulated optimal joint allometric scaling models of fat, shank weight (shank-w) and liver as well as thyroxine (T4) and glucose (GLC) to body weights. For body compositions, a total of 9 QTLs, including 4 additive and 5 dominant QTLs, were detected to control the allometric scalings of fat, shank-w, and liver to body weights; while a total of 10 QTLs of which 6 were dominant, were mapped to govern the allometries of T4 and GLC to body weights. We characterized relative growths of body compositions and metabolic traits to body weights in broilers with joint allometric scaling models and detected QTLs for the allometry scalings of the relative growths by using RRMs. The identified QTLs, including their highly linked genetic markers, could be used to order relative growths of the body components or metabolic traits to body weights in marker-assisted breeding programs for improving the standard and quality of broiler meat products.