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Antimicrobial Properties of the Ag, Cu Nanoparticle System

SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoper...

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Detalles Bibliográficos
Autores principales: Fan, Xinzhen, Yahia, L’Hocine, Sacher, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916421/
https://www.ncbi.nlm.nih.gov/pubmed/33578705
http://dx.doi.org/10.3390/biology10020137
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author Fan, Xinzhen
Yahia, L’Hocine
Sacher, Edward
author_facet Fan, Xinzhen
Yahia, L’Hocine
Sacher, Edward
author_sort Fan, Xinzhen
collection PubMed
description SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them.
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spelling pubmed-79164212021-03-01 Antimicrobial Properties of the Ag, Cu Nanoparticle System Fan, Xinzhen Yahia, L’Hocine Sacher, Edward Biology (Basel) Review SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them. MDPI 2021-02-10 /pmc/articles/PMC7916421/ /pubmed/33578705 http://dx.doi.org/10.3390/biology10020137 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fan, Xinzhen
Yahia, L’Hocine
Sacher, Edward
Antimicrobial Properties of the Ag, Cu Nanoparticle System
title Antimicrobial Properties of the Ag, Cu Nanoparticle System
title_full Antimicrobial Properties of the Ag, Cu Nanoparticle System
title_fullStr Antimicrobial Properties of the Ag, Cu Nanoparticle System
title_full_unstemmed Antimicrobial Properties of the Ag, Cu Nanoparticle System
title_short Antimicrobial Properties of the Ag, Cu Nanoparticle System
title_sort antimicrobial properties of the ag, cu nanoparticle system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916421/
https://www.ncbi.nlm.nih.gov/pubmed/33578705
http://dx.doi.org/10.3390/biology10020137
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