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Antimicrobial Properties of the Ag, Cu Nanoparticle System
SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoper...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916421/ https://www.ncbi.nlm.nih.gov/pubmed/33578705 http://dx.doi.org/10.3390/biology10020137 |
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author | Fan, Xinzhen Yahia, L’Hocine Sacher, Edward |
author_facet | Fan, Xinzhen Yahia, L’Hocine Sacher, Edward |
author_sort | Fan, Xinzhen |
collection | PubMed |
description | SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them. |
format | Online Article Text |
id | pubmed-7916421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79164212021-03-01 Antimicrobial Properties of the Ag, Cu Nanoparticle System Fan, Xinzhen Yahia, L’Hocine Sacher, Edward Biology (Basel) Review SIMPLE SUMMARY: The antimicrobial properties of Ag and Cu nanoparticles, their mixtures and their alloys, are reviewed. ABSTRACT: Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag–Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them. MDPI 2021-02-10 /pmc/articles/PMC7916421/ /pubmed/33578705 http://dx.doi.org/10.3390/biology10020137 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fan, Xinzhen Yahia, L’Hocine Sacher, Edward Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title | Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title_full | Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title_fullStr | Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title_full_unstemmed | Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title_short | Antimicrobial Properties of the Ag, Cu Nanoparticle System |
title_sort | antimicrobial properties of the ag, cu nanoparticle system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916421/ https://www.ncbi.nlm.nih.gov/pubmed/33578705 http://dx.doi.org/10.3390/biology10020137 |
work_keys_str_mv | AT fanxinzhen antimicrobialpropertiesoftheagcunanoparticlesystem AT yahialhocine antimicrobialpropertiesoftheagcunanoparticlesystem AT sacheredward antimicrobialpropertiesoftheagcunanoparticlesystem |