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Plant Natural Products: Promising Resources for Cancer Chemoprevention

Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sourc...

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Detalles Bibliográficos
Autores principales: Ma, Li, Zhang, Mengmeng, Zhao, Rong, Wang, Dan, Ma, Yuerong, Ai, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916513/
https://www.ncbi.nlm.nih.gov/pubmed/33578780
http://dx.doi.org/10.3390/molecules26040933
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author Ma, Li
Zhang, Mengmeng
Zhao, Rong
Wang, Dan
Ma, Yuerong
Ai, Li
author_facet Ma, Li
Zhang, Mengmeng
Zhao, Rong
Wang, Dan
Ma, Yuerong
Ai, Li
author_sort Ma, Li
collection PubMed
description Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sources and are a promising source for cancer chemoprevention. This article reviews the chemopreventive effects of natural products, especially focused on polyphenols, flavonoids, monoterpene and triterpenoids, sulfur compounds, and cellulose. Meanwhile, the main mechanisms include induction of apoptosis, antiproliferation and inhibition of metastasis are briefly summarized. In conclusion, this article provides evidence for natural products remaining a prominent source of cancer chemoprevention.
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spelling pubmed-79165132021-03-01 Plant Natural Products: Promising Resources for Cancer Chemoprevention Ma, Li Zhang, Mengmeng Zhao, Rong Wang, Dan Ma, Yuerong Ai, Li Molecules Review Cancer is a major factor threatening human health and life safety, and there is a lack of safe and effective therapeutic drugs. Intervention and prevention in premalignant process are effective ways to reverse carcinogenesis and prevent cancer from occurring. Plant natural products are rich in sources and are a promising source for cancer chemoprevention. This article reviews the chemopreventive effects of natural products, especially focused on polyphenols, flavonoids, monoterpene and triterpenoids, sulfur compounds, and cellulose. Meanwhile, the main mechanisms include induction of apoptosis, antiproliferation and inhibition of metastasis are briefly summarized. In conclusion, this article provides evidence for natural products remaining a prominent source of cancer chemoprevention. MDPI 2021-02-10 /pmc/articles/PMC7916513/ /pubmed/33578780 http://dx.doi.org/10.3390/molecules26040933 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ma, Li
Zhang, Mengmeng
Zhao, Rong
Wang, Dan
Ma, Yuerong
Ai, Li
Plant Natural Products: Promising Resources for Cancer Chemoprevention
title Plant Natural Products: Promising Resources for Cancer Chemoprevention
title_full Plant Natural Products: Promising Resources for Cancer Chemoprevention
title_fullStr Plant Natural Products: Promising Resources for Cancer Chemoprevention
title_full_unstemmed Plant Natural Products: Promising Resources for Cancer Chemoprevention
title_short Plant Natural Products: Promising Resources for Cancer Chemoprevention
title_sort plant natural products: promising resources for cancer chemoprevention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916513/
https://www.ncbi.nlm.nih.gov/pubmed/33578780
http://dx.doi.org/10.3390/molecules26040933
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