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Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study

Extraintestinal manifestations are common in patients with inflammatory bowel disease (IBD), and optic neuritis (ON) is a rare but severe one. This study aimed to evaluate possible factors associated with ON in patients with IBD. Adult patients with IBD who were not with concomitant ON on the index...

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Autores principales: Hsieh, Yun-Hsiu, Chung, Chi-Hsiang, Sun, Chien-An, Chen, Po-Huang, Chen, Yi-Hao, Liang, Chang-Min, Chen, Jiann-Torng, Chien, Wu-Chien, Chen, Ching-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916645/
https://www.ncbi.nlm.nih.gov/pubmed/33578895
http://dx.doi.org/10.3390/jcm10040688
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author Hsieh, Yun-Hsiu
Chung, Chi-Hsiang
Sun, Chien-An
Chen, Po-Huang
Chen, Yi-Hao
Liang, Chang-Min
Chen, Jiann-Torng
Chien, Wu-Chien
Chen, Ching-Long
author_facet Hsieh, Yun-Hsiu
Chung, Chi-Hsiang
Sun, Chien-An
Chen, Po-Huang
Chen, Yi-Hao
Liang, Chang-Min
Chen, Jiann-Torng
Chien, Wu-Chien
Chen, Ching-Long
author_sort Hsieh, Yun-Hsiu
collection PubMed
description Extraintestinal manifestations are common in patients with inflammatory bowel disease (IBD), and optic neuritis (ON) is a rare but severe one. This study aimed to evaluate possible factors associated with ON in patients with IBD. Adult patients with IBD who were not with concomitant ON on the index date identified from the Taiwan National Health Insurance Research Database (NHIRD) from the years 2000 to 2013 were included. A four-fold matched group was selected using age, sex and year of index date for comparison. All the patients were followed up until the development of ON or the end of the study period. Data of included patients were extracted and analyzed statistically. The mean follow-up time for all patients was 7.13 ± 5.21 years. At the study period conclusion, eight (0.18%) and five (0.003%) patients with and without IBD, respectively, had developed ON (p = 0.001). Adjusted HRs showed that patients with IBD aged between 30 and 39 years, with comorbidities including neuromyelitis optica (NMO), acute disseminated encephalomyelitis (ADEM), systemic lupus erythematosus (SLE) and with a higher Charlson Comorbidity Index, had a significantly higher risk of developing ON (all p < 0.005). Among the eight IBD patients who developed ON, only one patient was diagnosed with Crohn’s disease, the male gender was slightly dominant, and two (25%) patients received antitumor necrosis factor α (anti-TNF α) treatment for IBD. Patients with IBD have a higher risk of developing ON compared to patients without IBD. ON occurs more frequently in IBD patients aged between 30 and 39 years, with comorbidities including NMO, ADEM and SLE. Other factors besides anti-TNF α treatment for IBD are more likely associated with the development of ON.
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spelling pubmed-79166452021-03-01 Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study Hsieh, Yun-Hsiu Chung, Chi-Hsiang Sun, Chien-An Chen, Po-Huang Chen, Yi-Hao Liang, Chang-Min Chen, Jiann-Torng Chien, Wu-Chien Chen, Ching-Long J Clin Med Article Extraintestinal manifestations are common in patients with inflammatory bowel disease (IBD), and optic neuritis (ON) is a rare but severe one. This study aimed to evaluate possible factors associated with ON in patients with IBD. Adult patients with IBD who were not with concomitant ON on the index date identified from the Taiwan National Health Insurance Research Database (NHIRD) from the years 2000 to 2013 were included. A four-fold matched group was selected using age, sex and year of index date for comparison. All the patients were followed up until the development of ON or the end of the study period. Data of included patients were extracted and analyzed statistically. The mean follow-up time for all patients was 7.13 ± 5.21 years. At the study period conclusion, eight (0.18%) and five (0.003%) patients with and without IBD, respectively, had developed ON (p = 0.001). Adjusted HRs showed that patients with IBD aged between 30 and 39 years, with comorbidities including neuromyelitis optica (NMO), acute disseminated encephalomyelitis (ADEM), systemic lupus erythematosus (SLE) and with a higher Charlson Comorbidity Index, had a significantly higher risk of developing ON (all p < 0.005). Among the eight IBD patients who developed ON, only one patient was diagnosed with Crohn’s disease, the male gender was slightly dominant, and two (25%) patients received antitumor necrosis factor α (anti-TNF α) treatment for IBD. Patients with IBD have a higher risk of developing ON compared to patients without IBD. ON occurs more frequently in IBD patients aged between 30 and 39 years, with comorbidities including NMO, ADEM and SLE. Other factors besides anti-TNF α treatment for IBD are more likely associated with the development of ON. MDPI 2021-02-10 /pmc/articles/PMC7916645/ /pubmed/33578895 http://dx.doi.org/10.3390/jcm10040688 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsieh, Yun-Hsiu
Chung, Chi-Hsiang
Sun, Chien-An
Chen, Po-Huang
Chen, Yi-Hao
Liang, Chang-Min
Chen, Jiann-Torng
Chien, Wu-Chien
Chen, Ching-Long
Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title_full Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title_fullStr Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title_full_unstemmed Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title_short Association between Optic Neuritis and Inflammatory Bowel Disease: A Population-Based Study
title_sort association between optic neuritis and inflammatory bowel disease: a population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916645/
https://www.ncbi.nlm.nih.gov/pubmed/33578895
http://dx.doi.org/10.3390/jcm10040688
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