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Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells

SIMPLE SUMMARY: To understand the effect of metformin on epigenetic regulation, we analyzed histone H3 methylation, DNA methylation, and chromatin accessibility in lung cancer cells. Metformin showed little effect on DNA methylation or chromatin accessibility but significantly reduced H3K4me3 levels...

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Detalles Bibliográficos
Autores principales:	Kim, Dongho, Kim, Yujin, Lee, Bo Bin, Cho, Eun Yoon, Han, Joungho, Shim, Young Mog, Kim, Duk-Hwan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916663/ https://www.ncbi.nlm.nih.gov/pubmed/33578894 http://dx.doi.org/10.3390/cancers13040739

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