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Suppressed Hepatic Production of Indoxyl Sulfate Attenuates Cisplatin-Induced Acute Kidney Injury in Sulfotransferase 1a1-Deficient Mice

Endogenous factors involved in the progression of cisplatin nephropathy remain undetermined. Here, we demonstrate the toxico-pathological roles of indoxyl sulfate (IS), a sulfate-conjugated uremic toxin, and sulfotransferase 1A1 (SULT1A1), an enzyme involved in its synthesis, in cisplatin-induced ac...

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Detalles Bibliográficos
Autores principales:	Yabuuchi, Nozomi, Hou, Huixian, Gunda, Nao, Narita, Yuki, Jono, Hirofumi, Saito, Hideyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916706/ https://www.ncbi.nlm.nih.gov/pubmed/33578912 http://dx.doi.org/10.3390/ijms22041764

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