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Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?

Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and have some malignant potential. Mitotic count is important for predicting the malignant potential of GISTs. Proper treatment of GISTs requires accurate pathological diagnosis. In general, endoscopic ultrasound-guided fine-...

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Autores principales: Choi, Seong Ji, Lee, Kwan Hong, Yoo, Chan Kyoo, Yoon, Jai Hoon, Jang, Ki Seok, Kim, Youn Jeong, Lee, Hang Lak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916709/
https://www.ncbi.nlm.nih.gov/pubmed/33578901
http://dx.doi.org/10.3390/jcm10040687
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author Choi, Seong Ji
Lee, Kwan Hong
Yoo, Chan Kyoo
Yoon, Jai Hoon
Jang, Ki Seok
Kim, Youn Jeong
Lee, Hang Lak
author_facet Choi, Seong Ji
Lee, Kwan Hong
Yoo, Chan Kyoo
Yoon, Jai Hoon
Jang, Ki Seok
Kim, Youn Jeong
Lee, Hang Lak
author_sort Choi, Seong Ji
collection PubMed
description Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and have some malignant potential. Mitotic count is important for predicting the malignant potential of GISTs. Proper treatment of GISTs requires accurate pathological diagnosis. In general, endoscopic ultrasound-guided fine-needle aspiration and deep biopsy are used for pathological diagnosis of GIST before making decisions about surgery. This study sought to evaluate the pathological uniformity of gastric GISTs for mitotic index of the center and periphery of the GIST. Methods: We retrospectively reviewed the data of 37 gastric GIST patients who underwent wedge resection at Hanyang University Hospital. We used Armed Forces Institute of Pathology criteria to classify gastric GISTs. To determine the pathological uniformity of gastric GISTs, we compared GIST risk stratification between the center and periphery of GISTs. Results: The mean size of GISTs was 3.56 ± 2.10 cm. Three lesions were located in the antrum, 11 in the fundus, 9 in the cardia, and 14 in the body. The mean age of patients was 58.65 ± 9.44 years; 18 patients were male and 19 were female. Thirty-five patients (94.6%) showed the same level of risk stratification between the center and periphery of gastric GISTs, while two patients (5.4%) presented different levels of risk between the two sites. No significant difference in mitotic count was observed between the two sites (kappa value = 0.863; p = 0.001). Conclusions: Mitotic index category (either more than five mitoses per high-power field or five or fewer mitoses per high-power field) of GISTs showed good concurrence between the center and periphery.
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spelling pubmed-79167092021-03-01 Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor? Choi, Seong Ji Lee, Kwan Hong Yoo, Chan Kyoo Yoon, Jai Hoon Jang, Ki Seok Kim, Youn Jeong Lee, Hang Lak J Clin Med Article Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors and have some malignant potential. Mitotic count is important for predicting the malignant potential of GISTs. Proper treatment of GISTs requires accurate pathological diagnosis. In general, endoscopic ultrasound-guided fine-needle aspiration and deep biopsy are used for pathological diagnosis of GIST before making decisions about surgery. This study sought to evaluate the pathological uniformity of gastric GISTs for mitotic index of the center and periphery of the GIST. Methods: We retrospectively reviewed the data of 37 gastric GIST patients who underwent wedge resection at Hanyang University Hospital. We used Armed Forces Institute of Pathology criteria to classify gastric GISTs. To determine the pathological uniformity of gastric GISTs, we compared GIST risk stratification between the center and periphery of GISTs. Results: The mean size of GISTs was 3.56 ± 2.10 cm. Three lesions were located in the antrum, 11 in the fundus, 9 in the cardia, and 14 in the body. The mean age of patients was 58.65 ± 9.44 years; 18 patients were male and 19 were female. Thirty-five patients (94.6%) showed the same level of risk stratification between the center and periphery of gastric GISTs, while two patients (5.4%) presented different levels of risk between the two sites. No significant difference in mitotic count was observed between the two sites (kappa value = 0.863; p = 0.001). Conclusions: Mitotic index category (either more than five mitoses per high-power field or five or fewer mitoses per high-power field) of GISTs showed good concurrence between the center and periphery. MDPI 2021-02-10 /pmc/articles/PMC7916709/ /pubmed/33578901 http://dx.doi.org/10.3390/jcm10040687 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Seong Ji
Lee, Kwan Hong
Yoo, Chan Kyoo
Yoon, Jai Hoon
Jang, Ki Seok
Kim, Youn Jeong
Lee, Hang Lak
Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title_full Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title_fullStr Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title_full_unstemmed Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title_short Is There Pathological Uniformity between the Periphery and Center of a Gastrointestinal Stromal Tumor?
title_sort is there pathological uniformity between the periphery and center of a gastrointestinal stromal tumor?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916709/
https://www.ncbi.nlm.nih.gov/pubmed/33578901
http://dx.doi.org/10.3390/jcm10040687
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