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Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury

Trimethoprim (TMP)-induced skin rash and liver injury are likely to involve the formation of reactive metabolites. Analogous to nevirapine-induced skin rash, 1 possible reactive metabolite is the sulfate conjugate of α-hydroxyTMP, a metabolite of TMP. We synthesized this sulfate and found that it re...

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Detalles Bibliográficos
Autores principales:	Cao, Yanshan, Bairam, Ahsan, Jee, Alison, Liu, Ming, Uetrecht, Jack
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Biotransformation, Toxicokinetics, and Pharmacokinetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916736/ https://www.ncbi.nlm.nih.gov/pubmed/33394045 http://dx.doi.org/10.1093/toxsci/kfaa182

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