A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin

Microtubules composed of α/β tubulin heterodimers are an essential part of the cytoskeleton of eukaryotic cells and are widely regarded as targets for cancer chemotherapy. IC261, which is discovered as an ATP-competitive inhibitor of serine/threonine-specific casein kinase 1 (CK1), has shown its inh...

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Detalles Bibliográficos
Autores principales: Xian, Jinghong, Bu, Faqian, Wang, Yuxi, Long, Fangyi, Zhang, Zhixiong, Wu, Chengyong, Tao, Yiran, Wang, Ting, Wang, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916759/
https://www.ncbi.nlm.nih.gov/pubmed/33579052
http://dx.doi.org/10.3390/molecules26040946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916759/
https://www.ncbi.nlm.nih.gov/pubmed/33579052
http://dx.doi.org/10.3390/molecules26040946

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