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Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice
Neuroinflammation plays an essential role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease. Although coumarins have been shown to improve cognitive function in animal models and exert anti-inflammatory effects in cell cultures, the exact mechanism of their neuroprotectiv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916770/ https://www.ncbi.nlm.nih.gov/pubmed/33579030 http://dx.doi.org/10.3390/ijms22041779 |
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author | Kurach, Łukasz Kulczycka-Mamona, Sylwia Kowalczyk, Joanna Skalicka-Woźniak, Krystyna Boguszewska-Czubara, Anna El Sayed, Nesrine Osmani, Mitat Iwaniak, Karol Budzyńska, Barbara |
author_facet | Kurach, Łukasz Kulczycka-Mamona, Sylwia Kowalczyk, Joanna Skalicka-Woźniak, Krystyna Boguszewska-Czubara, Anna El Sayed, Nesrine Osmani, Mitat Iwaniak, Karol Budzyńska, Barbara |
author_sort | Kurach, Łukasz |
collection | PubMed |
description | Neuroinflammation plays an essential role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease. Although coumarins have been shown to improve cognitive function in animal models and exert anti-inflammatory effects in cell cultures, the exact mechanism of their neuroprotective effects has not yet been fully elucidated. The present study aimed to investigate the neuroprotective effects of xanthotoxin (furanocoumarin) and umbelliferone (simple coumarin) in lipopolysaccharide-induced cognitive dysfunction in mice. For evaluation memory and learning processes, a passive avoidance test was used. Furthermore, acetylcholinesterase level and impact on the tumor necrosis factor α, interleukin 10 levels in the whole brain, and cyclooxygenase-II in hippocampus was established. Subchronic administration of both coumarins (15 mg/kg) enhanced the learning and memory function, but only the xanthotoxin improved cognitive processes impaired by lipopolysaccharide (0.8 mg/kg) administration. Behavioral results stay in line with acetylcholinesterase level in the brain. A statistically significant decrease in the level of tumor necrosis factor α and cyclooxygenase-II in lipopolysaccharide-treated rodents after coumarins’ administration was observed. Together, our findings demonstrate that both coumarins improved cognitive functions, but only xanthotoxin significantly enhanced the learning and memory function and reduced the level of acetylcholinesterase in lipopolysaccharide-treated mice. This effect may suggest that only furanocoumarin—xanthotoxin attenuates neuroinflammation and enhances cholinergic neurotransmission, thus it can be a potential remedy with procognitive potential effective in treatment of neuroinflammatory disease. |
format | Online Article Text |
id | pubmed-7916770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79167702021-03-01 Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice Kurach, Łukasz Kulczycka-Mamona, Sylwia Kowalczyk, Joanna Skalicka-Woźniak, Krystyna Boguszewska-Czubara, Anna El Sayed, Nesrine Osmani, Mitat Iwaniak, Karol Budzyńska, Barbara Int J Mol Sci Article Neuroinflammation plays an essential role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease. Although coumarins have been shown to improve cognitive function in animal models and exert anti-inflammatory effects in cell cultures, the exact mechanism of their neuroprotective effects has not yet been fully elucidated. The present study aimed to investigate the neuroprotective effects of xanthotoxin (furanocoumarin) and umbelliferone (simple coumarin) in lipopolysaccharide-induced cognitive dysfunction in mice. For evaluation memory and learning processes, a passive avoidance test was used. Furthermore, acetylcholinesterase level and impact on the tumor necrosis factor α, interleukin 10 levels in the whole brain, and cyclooxygenase-II in hippocampus was established. Subchronic administration of both coumarins (15 mg/kg) enhanced the learning and memory function, but only the xanthotoxin improved cognitive processes impaired by lipopolysaccharide (0.8 mg/kg) administration. Behavioral results stay in line with acetylcholinesterase level in the brain. A statistically significant decrease in the level of tumor necrosis factor α and cyclooxygenase-II in lipopolysaccharide-treated rodents after coumarins’ administration was observed. Together, our findings demonstrate that both coumarins improved cognitive functions, but only xanthotoxin significantly enhanced the learning and memory function and reduced the level of acetylcholinesterase in lipopolysaccharide-treated mice. This effect may suggest that only furanocoumarin—xanthotoxin attenuates neuroinflammation and enhances cholinergic neurotransmission, thus it can be a potential remedy with procognitive potential effective in treatment of neuroinflammatory disease. MDPI 2021-02-10 /pmc/articles/PMC7916770/ /pubmed/33579030 http://dx.doi.org/10.3390/ijms22041779 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kurach, Łukasz Kulczycka-Mamona, Sylwia Kowalczyk, Joanna Skalicka-Woźniak, Krystyna Boguszewska-Czubara, Anna El Sayed, Nesrine Osmani, Mitat Iwaniak, Karol Budzyńska, Barbara Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title | Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title_full | Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title_fullStr | Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title_full_unstemmed | Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title_short | Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice |
title_sort | mechanisms of the procognitive effects of xanthotoxin and umbelliferone on lps-induced amnesia in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916770/ https://www.ncbi.nlm.nih.gov/pubmed/33579030 http://dx.doi.org/10.3390/ijms22041779 |
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