Cargando…

Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study

Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal...

Descripción completa

Detalles Bibliográficos
Autores principales: Kanakoudi-Tsakalidou, Florentia, Farmaki, Evangelia, Papadimitriou, Eleni, Taparkou, Anna, Agakidou, Eleni, Glykou, Styliani, Papachristou, Fotiοs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916772/
https://www.ncbi.nlm.nih.gov/pubmed/33579024
http://dx.doi.org/10.3390/vaccines9020143
_version_ 1783657553047060480
author Kanakoudi-Tsakalidou, Florentia
Farmaki, Evangelia
Papadimitriou, Eleni
Taparkou, Anna
Agakidou, Eleni
Glykou, Styliani
Papachristou, Fotiοs
author_facet Kanakoudi-Tsakalidou, Florentia
Farmaki, Evangelia
Papadimitriou, Eleni
Taparkou, Anna
Agakidou, Eleni
Glykou, Styliani
Papachristou, Fotiοs
author_sort Kanakoudi-Tsakalidou, Florentia
collection PubMed
description Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants’ antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions.
format Online
Article
Text
id pubmed-7916772
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-79167722021-03-01 Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study Kanakoudi-Tsakalidou, Florentia Farmaki, Evangelia Papadimitriou, Eleni Taparkou, Anna Agakidou, Eleni Glykou, Styliani Papachristou, Fotiοs Vaccines (Basel) Article Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants’ antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions. MDPI 2021-02-10 /pmc/articles/PMC7916772/ /pubmed/33579024 http://dx.doi.org/10.3390/vaccines9020143 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanakoudi-Tsakalidou, Florentia
Farmaki, Evangelia
Papadimitriou, Eleni
Taparkou, Anna
Agakidou, Eleni
Glykou, Styliani
Papachristou, Fotiοs
Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title_full Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title_fullStr Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title_full_unstemmed Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title_short Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study
title_sort humoral immunity against measles in mother–infant pairs during the first year of life in greece: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916772/
https://www.ncbi.nlm.nih.gov/pubmed/33579024
http://dx.doi.org/10.3390/vaccines9020143
work_keys_str_mv AT kanakouditsakalidouflorentia humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT farmakievangelia humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT papadimitrioueleni humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT taparkouanna humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT agakidoueleni humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT glykoustyliani humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy
AT papachristoufotios humoralimmunityagainstmeaslesinmotherinfantpairsduringthefirstyearoflifeingreeceacrosssectionalstudy