Cargando…
Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men
Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional stud...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916849/ https://www.ncbi.nlm.nih.gov/pubmed/33670148 http://dx.doi.org/10.3390/ijerph18041742 |
_version_ | 1783657571201056768 |
---|---|
author | Benson, Thea Emily Gaml-Sørensen, Anne Ernst, Andreas Brix, Nis Hougaard, Karin Sørig Hærvig, Katia Keglberg Ellekilde Bonde, Jens Peter Tøttenborg, Sandra Søgaard Lindh, Christian H. Ramlau-Hansen, Cecilia Høst Toft, Gunnar |
author_facet | Benson, Thea Emily Gaml-Sørensen, Anne Ernst, Andreas Brix, Nis Hougaard, Karin Sørig Hærvig, Katia Keglberg Ellekilde Bonde, Jens Peter Tøttenborg, Sandra Søgaard Lindh, Christian H. Ramlau-Hansen, Cecilia Høst Toft, Gunnar |
author_sort | Benson, Thea Emily |
collection | PubMed |
description | Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population. |
format | Online Article Text |
id | pubmed-7916849 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79168492021-03-01 Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men Benson, Thea Emily Gaml-Sørensen, Anne Ernst, Andreas Brix, Nis Hougaard, Karin Sørig Hærvig, Katia Keglberg Ellekilde Bonde, Jens Peter Tøttenborg, Sandra Søgaard Lindh, Christian H. Ramlau-Hansen, Cecilia Høst Toft, Gunnar Int J Environ Res Public Health Article Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross–sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population. MDPI 2021-02-11 2021-02 /pmc/articles/PMC7916849/ /pubmed/33670148 http://dx.doi.org/10.3390/ijerph18041742 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Benson, Thea Emily Gaml-Sørensen, Anne Ernst, Andreas Brix, Nis Hougaard, Karin Sørig Hærvig, Katia Keglberg Ellekilde Bonde, Jens Peter Tøttenborg, Sandra Søgaard Lindh, Christian H. Ramlau-Hansen, Cecilia Høst Toft, Gunnar Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title | Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title_full | Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title_fullStr | Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title_full_unstemmed | Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title_short | Urinary Bisphenol A, F and S Levels and Semen Quality in Young Adult Danish Men |
title_sort | urinary bisphenol a, f and s levels and semen quality in young adult danish men |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916849/ https://www.ncbi.nlm.nih.gov/pubmed/33670148 http://dx.doi.org/10.3390/ijerph18041742 |
work_keys_str_mv | AT bensontheaemily urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT gamlsørensenanne urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT ernstandreas urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT brixnis urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT hougaardkarinsørig urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT hærvigkatiakeglberg urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT ellekildebondejenspeter urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT tøttenborgsandrasøgaard urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT lindhchristianh urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT ramlauhansenceciliahøst urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen AT toftgunnar urinarybisphenolafandslevelsandsemenqualityinyoungadultdanishmen |