Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells

Since genes encoding epigenetic regulators are often mutated or deregulated in urothelial carcinoma (UC), they represent promising therapeutic targets. Specifically, inhibition of Class-I histone deacetylase (HDAC) isoenzymes induces cell death in UC cell lines (UCC) and, in contrast to other cancer...

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Detalles Bibliográficos
Autores principales: Hoffmann, Michèle J., Meneceur, Sarah, Hommel, Katrin, Schulz, Wolfgang A., Niegisch, Günter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916885/
https://www.ncbi.nlm.nih.gov/pubmed/33670166
http://dx.doi.org/10.3390/genes12020260

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