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The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection
De novo viral protein synthesis following entry into host cells is essential for viral replication. As a consequence, viruses have evolved mechanisms to engage the host translational machinery while at the same time avoiding or counteracting host defenses that act to repress translation. Mammalian o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916891/ https://www.ncbi.nlm.nih.gov/pubmed/33670092 http://dx.doi.org/10.3390/v13020275 |
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author | Guo, Yingying Parker, John S. L. |
author_facet | Guo, Yingying Parker, John S. L. |
author_sort | Guo, Yingying |
collection | PubMed |
description | De novo viral protein synthesis following entry into host cells is essential for viral replication. As a consequence, viruses have evolved mechanisms to engage the host translational machinery while at the same time avoiding or counteracting host defenses that act to repress translation. Mammalian orthoreoviruses are dsRNA-containing viruses whose mRNAs were used as models for early investigations into the mechanisms that underpin the recognition and engagement of eukaryotic mRNAs by host cell ribosomes. However, there remain many unanswered questions and paradoxes regarding translation of reoviral mRNAs in the context of infection. This review summarizes the current state of knowledge about reovirus translation, identifies key unanswered questions, and proposes possible pathways toward a better understanding of reovirus translation. |
format | Online Article Text |
id | pubmed-7916891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79168912021-03-01 The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection Guo, Yingying Parker, John S. L. Viruses Review De novo viral protein synthesis following entry into host cells is essential for viral replication. As a consequence, viruses have evolved mechanisms to engage the host translational machinery while at the same time avoiding or counteracting host defenses that act to repress translation. Mammalian orthoreoviruses are dsRNA-containing viruses whose mRNAs were used as models for early investigations into the mechanisms that underpin the recognition and engagement of eukaryotic mRNAs by host cell ribosomes. However, there remain many unanswered questions and paradoxes regarding translation of reoviral mRNAs in the context of infection. This review summarizes the current state of knowledge about reovirus translation, identifies key unanswered questions, and proposes possible pathways toward a better understanding of reovirus translation. MDPI 2021-02-11 /pmc/articles/PMC7916891/ /pubmed/33670092 http://dx.doi.org/10.3390/v13020275 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Guo, Yingying Parker, John S. L. The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title | The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title_full | The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title_fullStr | The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title_full_unstemmed | The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title_short | The Paradoxes of Viral mRNA Translation during Mammalian Orthoreovirus Infection |
title_sort | paradoxes of viral mrna translation during mammalian orthoreovirus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916891/ https://www.ncbi.nlm.nih.gov/pubmed/33670092 http://dx.doi.org/10.3390/v13020275 |
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